Obesity and Metabolic Phenotypes (Metabolically Healthy and Unhealthy Variants) Are Significantly Associated with Prevalence of Elevated C-Reactive Protein and Hepatic Steatosis in a Large Healthy Brazilian Population
المؤلفون المشاركون
Shaharyar, Sameer
Roberson, Lara L.
Jamal, Omar
Younus, Adnan
Blaha, Michael J.
Ali, Shozab S.
Zide, Kenneth
Agatston, Arthur A.
Blumenthal, Roger S.
Conceição, Raquel D.
Santos, Raul D.
Nasir, Khurram
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-09
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Among the obese, the so-called metabolically healthy obese (MHO) phenotype is thought to confer a lower CVD risk as compared to obesity with typical associated metabolic changes.
The present study aims to determine the relationship of different subtypes of obesity with inflammatory-cardiometabolic abnormalities.
Methods.
We evaluated 5,519 healthy, Brazilian subjects (43±10 years, 78% males), free of known cardiovascular disease.
Those with <2 metabolic risk factors (MRF) were considered metabolically healthy, and those with BMI ≥ 25 kg/m2 and/or waist circumference meeting NCEP criteria for metabolic syndrome as overweight/obese (OW).
High sensitivity C reactive protein (hsCRP) was measured to assess underlying inflammation and hepatic steatosis (HS) was determined via abdominal ultrasound.
Results.
Overall, 40% of OW individuals were metabolically healthy, and 12% normal-weight had ≥2 MRF.
The prevalence of elevated CRP (≥3 mg/dL) and HS in MHO versus normal weight metabolically healthy group was 22% versus 12%, and 40% versus 8% respectively (P<0.001).
Both MHO individuals and metabolically unhealthy normal weight (MUNW) phenotypes were associated with elevated hsCRP and HS.
Conclusion.
Our study suggests that MHO and MUNW phenotypes may not be benign and physicians should strive to treat individuals in these subgroups to reverse these conditions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shaharyar, Sameer& Roberson, Lara L.& Jamal, Omar& Younus, Adnan& Blaha, Michael J.& Ali, Shozab S.…[et al.]. 2015. Obesity and Metabolic Phenotypes (Metabolically Healthy and Unhealthy Variants) Are Significantly Associated with Prevalence of Elevated C-Reactive Protein and Hepatic Steatosis in a Large Healthy Brazilian Population. Journal of Obesity،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1069595
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shaharyar, Sameer…[et al.]. Obesity and Metabolic Phenotypes (Metabolically Healthy and Unhealthy Variants) Are Significantly Associated with Prevalence of Elevated C-Reactive Protein and Hepatic Steatosis in a Large Healthy Brazilian Population. Journal of Obesity No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1069595
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shaharyar, Sameer& Roberson, Lara L.& Jamal, Omar& Younus, Adnan& Blaha, Michael J.& Ali, Shozab S.…[et al.]. Obesity and Metabolic Phenotypes (Metabolically Healthy and Unhealthy Variants) Are Significantly Associated with Prevalence of Elevated C-Reactive Protein and Hepatic Steatosis in a Large Healthy Brazilian Population. Journal of Obesity. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1069595
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1069595
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر