Obesity and Metabolic Phenotypes (Metabolically Healthy and Unhealthy Variants) Are Significantly Associated with Prevalence of Elevated C-Reactive Protein and Hepatic Steatosis in a Large Healthy Brazilian Population
Joint Authors
Shaharyar, Sameer
Roberson, Lara L.
Jamal, Omar
Younus, Adnan
Blaha, Michael J.
Ali, Shozab S.
Zide, Kenneth
Agatston, Arthur A.
Blumenthal, Roger S.
Conceição, Raquel D.
Santos, Raul D.
Nasir, Khurram
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Among the obese, the so-called metabolically healthy obese (MHO) phenotype is thought to confer a lower CVD risk as compared to obesity with typical associated metabolic changes.
The present study aims to determine the relationship of different subtypes of obesity with inflammatory-cardiometabolic abnormalities.
Methods.
We evaluated 5,519 healthy, Brazilian subjects (43±10 years, 78% males), free of known cardiovascular disease.
Those with <2 metabolic risk factors (MRF) were considered metabolically healthy, and those with BMI ≥ 25 kg/m2 and/or waist circumference meeting NCEP criteria for metabolic syndrome as overweight/obese (OW).
High sensitivity C reactive protein (hsCRP) was measured to assess underlying inflammation and hepatic steatosis (HS) was determined via abdominal ultrasound.
Results.
Overall, 40% of OW individuals were metabolically healthy, and 12% normal-weight had ≥2 MRF.
The prevalence of elevated CRP (≥3 mg/dL) and HS in MHO versus normal weight metabolically healthy group was 22% versus 12%, and 40% versus 8% respectively (P<0.001).
Both MHO individuals and metabolically unhealthy normal weight (MUNW) phenotypes were associated with elevated hsCRP and HS.
Conclusion.
Our study suggests that MHO and MUNW phenotypes may not be benign and physicians should strive to treat individuals in these subgroups to reverse these conditions.
American Psychological Association (APA)
Shaharyar, Sameer& Roberson, Lara L.& Jamal, Omar& Younus, Adnan& Blaha, Michael J.& Ali, Shozab S.…[et al.]. 2015. Obesity and Metabolic Phenotypes (Metabolically Healthy and Unhealthy Variants) Are Significantly Associated with Prevalence of Elevated C-Reactive Protein and Hepatic Steatosis in a Large Healthy Brazilian Population. Journal of Obesity،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1069595
Modern Language Association (MLA)
Shaharyar, Sameer…[et al.]. Obesity and Metabolic Phenotypes (Metabolically Healthy and Unhealthy Variants) Are Significantly Associated with Prevalence of Elevated C-Reactive Protein and Hepatic Steatosis in a Large Healthy Brazilian Population. Journal of Obesity No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1069595
American Medical Association (AMA)
Shaharyar, Sameer& Roberson, Lara L.& Jamal, Omar& Younus, Adnan& Blaha, Michael J.& Ali, Shozab S.…[et al.]. Obesity and Metabolic Phenotypes (Metabolically Healthy and Unhealthy Variants) Are Significantly Associated with Prevalence of Elevated C-Reactive Protein and Hepatic Steatosis in a Large Healthy Brazilian Population. Journal of Obesity. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1069595
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069595