Association between Ophthalmic Timolol and Hospitalisation for Bradycardia
المؤلفون المشاركون
Pratt, Nicole L.
Ramsay, Emmae N.
Kalisch Ellett, Lisa M.
Nguyen, Tuan A.
Roughead, Elizabeth E.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-22
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Introduction.
Ophthalmic timolol, a topical nonselective beta-blocker, has the potential to be absorbed systemically which may cause adverse cardiovascular effects.
This study was conducted to determine whether initiation of ophthalmic timolol was associated with an increased risk of hospitalisation for bradycardia.
Materials and Methods.
A self-controlled case-series study was undertaken in patients who were hospitalised for bradycardia and were exposed to timolol.
Person-time after timolol initiation was partitioned into risk periods: 1–30 days, 31–180 days, and >180 days.
A 30-day risk period prior to initiating timolol was also included.
All remaining time was considered unexposed.
Results.
There were 6,373 patients with at least one hospitalisation for bradycardia during the study period; 267 were exposed to timolol.
Risk of bradycardia was significantly increased in the 31–180 days after timolol initiation (incidence rate ratio (IRR) = 1.93; 95% confidence interval (CI) 1.00–1.87).
No increased risk was observed in the first 30 days or beyond 180 days of continuous exposure (IRR = 1.40; 95% CI 0.87–2.26 and IRR = 1.21; 95% CI 0.64–2.31, resp.).
Conclusion.
Bradycardia is a potential adverse event following timolol initiation.
Practitioners should consider patient history before choosing a glaucoma regime and closely monitor patients after treatment initiation with topical nonselective beta-blocker eye drops.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pratt, Nicole L.& Ramsay, Emmae N.& Kalisch Ellett, Lisa M.& Nguyen, Tuan A.& Roughead, Elizabeth E.. 2015. Association between Ophthalmic Timolol and Hospitalisation for Bradycardia. Journal of Ophthalmology،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1069772
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pratt, Nicole L.…[et al.]. Association between Ophthalmic Timolol and Hospitalisation for Bradycardia. Journal of Ophthalmology No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1069772
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pratt, Nicole L.& Ramsay, Emmae N.& Kalisch Ellett, Lisa M.& Nguyen, Tuan A.& Roughead, Elizabeth E.. Association between Ophthalmic Timolol and Hospitalisation for Bradycardia. Journal of Ophthalmology. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1069772
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1069772
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر