Association between Ophthalmic Timolol and Hospitalisation for Bradycardia
Joint Authors
Pratt, Nicole L.
Ramsay, Emmae N.
Kalisch Ellett, Lisa M.
Nguyen, Tuan A.
Roughead, Elizabeth E.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Ophthalmic timolol, a topical nonselective beta-blocker, has the potential to be absorbed systemically which may cause adverse cardiovascular effects.
This study was conducted to determine whether initiation of ophthalmic timolol was associated with an increased risk of hospitalisation for bradycardia.
Materials and Methods.
A self-controlled case-series study was undertaken in patients who were hospitalised for bradycardia and were exposed to timolol.
Person-time after timolol initiation was partitioned into risk periods: 1–30 days, 31–180 days, and >180 days.
A 30-day risk period prior to initiating timolol was also included.
All remaining time was considered unexposed.
Results.
There were 6,373 patients with at least one hospitalisation for bradycardia during the study period; 267 were exposed to timolol.
Risk of bradycardia was significantly increased in the 31–180 days after timolol initiation (incidence rate ratio (IRR) = 1.93; 95% confidence interval (CI) 1.00–1.87).
No increased risk was observed in the first 30 days or beyond 180 days of continuous exposure (IRR = 1.40; 95% CI 0.87–2.26 and IRR = 1.21; 95% CI 0.64–2.31, resp.).
Conclusion.
Bradycardia is a potential adverse event following timolol initiation.
Practitioners should consider patient history before choosing a glaucoma regime and closely monitor patients after treatment initiation with topical nonselective beta-blocker eye drops.
American Psychological Association (APA)
Pratt, Nicole L.& Ramsay, Emmae N.& Kalisch Ellett, Lisa M.& Nguyen, Tuan A.& Roughead, Elizabeth E.. 2015. Association between Ophthalmic Timolol and Hospitalisation for Bradycardia. Journal of Ophthalmology،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1069772
Modern Language Association (MLA)
Pratt, Nicole L.…[et al.]. Association between Ophthalmic Timolol and Hospitalisation for Bradycardia. Journal of Ophthalmology No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1069772
American Medical Association (AMA)
Pratt, Nicole L.& Ramsay, Emmae N.& Kalisch Ellett, Lisa M.& Nguyen, Tuan A.& Roughead, Elizabeth E.. Association between Ophthalmic Timolol and Hospitalisation for Bradycardia. Journal of Ophthalmology. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1069772
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069772