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Iron Deprivation Affects Drug Susceptibilities of Mycobacteria Targeting Membrane Integrity
المؤلفون المشاركون
Pal, Rahul
Fatima, Zeeshan
Hameed, Saif
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-08
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Multidrug resistance (MDR) acquired by Mycobacterium tuberculosis (MTB) through continuous deployment of antitubercular drugs warrants immediate search for novel targets and mechanisms.
The ability of MTB to sense and become accustomed to changes in the host is essential for survival and confers the basis of infection.
A crucial condition that MTB must surmount is iron limitation, during the establishment of infection, since iron is required by both bacteria and humans.
This study focuses on how iron deprivation affects drug susceptibilities of known anti-TB drugs in Mycobacterium smegmatis, a “surrogate of MTB.” We showed that iron deprivation leads to enhanced potency of most commonly used first line anti-TB drugs that could be reverted upon iron supplementation.
We explored that membrane homeostasis is disrupted upon iron deprivation as revealed by enhanced membrane permeability and hypersensitivity to membrane perturbing agent leading to increased passive diffusion of drug and TEM images showing detectable differences in cell envelope thickness.
Furthermore, iron seems to be indispensable to sustain genotoxic stress suggesting its possible role in DNA repair machinery.
Taken together, we for the first time established a link between cellular iron and drug susceptibility of mycobacteria suggesting iron as novel determinant to combat MDR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pal, Rahul& Hameed, Saif& Fatima, Zeeshan. 2015. Iron Deprivation Affects Drug Susceptibilities of Mycobacteria Targeting Membrane Integrity. Journal of Pathogens،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1069955
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pal, Rahul…[et al.]. Iron Deprivation Affects Drug Susceptibilities of Mycobacteria Targeting Membrane Integrity. Journal of Pathogens No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1069955
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pal, Rahul& Hameed, Saif& Fatima, Zeeshan. Iron Deprivation Affects Drug Susceptibilities of Mycobacteria Targeting Membrane Integrity. Journal of Pathogens. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1069955
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1069955
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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