Iron Deprivation Affects Drug Susceptibilities of Mycobacteria Targeting Membrane Integrity
Joint Authors
Pal, Rahul
Fatima, Zeeshan
Hameed, Saif
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Multidrug resistance (MDR) acquired by Mycobacterium tuberculosis (MTB) through continuous deployment of antitubercular drugs warrants immediate search for novel targets and mechanisms.
The ability of MTB to sense and become accustomed to changes in the host is essential for survival and confers the basis of infection.
A crucial condition that MTB must surmount is iron limitation, during the establishment of infection, since iron is required by both bacteria and humans.
This study focuses on how iron deprivation affects drug susceptibilities of known anti-TB drugs in Mycobacterium smegmatis, a “surrogate of MTB.” We showed that iron deprivation leads to enhanced potency of most commonly used first line anti-TB drugs that could be reverted upon iron supplementation.
We explored that membrane homeostasis is disrupted upon iron deprivation as revealed by enhanced membrane permeability and hypersensitivity to membrane perturbing agent leading to increased passive diffusion of drug and TEM images showing detectable differences in cell envelope thickness.
Furthermore, iron seems to be indispensable to sustain genotoxic stress suggesting its possible role in DNA repair machinery.
Taken together, we for the first time established a link between cellular iron and drug susceptibility of mycobacteria suggesting iron as novel determinant to combat MDR.
American Psychological Association (APA)
Pal, Rahul& Hameed, Saif& Fatima, Zeeshan. 2015. Iron Deprivation Affects Drug Susceptibilities of Mycobacteria Targeting Membrane Integrity. Journal of Pathogens،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1069955
Modern Language Association (MLA)
Pal, Rahul…[et al.]. Iron Deprivation Affects Drug Susceptibilities of Mycobacteria Targeting Membrane Integrity. Journal of Pathogens No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1069955
American Medical Association (AMA)
Pal, Rahul& Hameed, Saif& Fatima, Zeeshan. Iron Deprivation Affects Drug Susceptibilities of Mycobacteria Targeting Membrane Integrity. Journal of Pathogens. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1069955
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1069955