Cytokine Profiles and Cell Proliferation Responses to Truncated ORF2 Protein in Iranian Patients Recovered from Hepatitis E Infection
المؤلفون المشاركون
Tajbakhsh, Saeed
Taherkhani, Reza
Farshadpour, Fatemeh
Makvandi, Manoochehr
Rajabi Memari, Hamid
Samarbafzadeh, Ali Reza
Sharifi, Nasrin
Naeimi, Behrouz
Akbarzadeh, Samad
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-15
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
The aim of this study was to evaluate hepatitis E virus (HEV) specific cellular immune responses to truncated ORF2 protein in Iranian patients recovered from HEV infection.
Information about HEV-specific immune responses could be useful in finding an effective way for development of HEV vaccine.
Methods.
A truncated form of HEV ORF2 protein containing amino acids 112-608 was used to stimulate peripheral blood mononuclear cells (PBMCs) separated from HEV-recovered and control groups.
Finally, the levels of four cytokines, IFN-γ ELISPOT, and cell proliferative responses following stimulation with the truncated ORF2 protein were assessed in the both groups.
Results.
The truncated ORF2 protein was able to induce IFN-γ ELISPOT and cell proliferation responses and to produce significant amounts of IFN-γ and IL-12 cytokines, but low amounts of IL-10 and IL-4 cytokines in vitro.
These responses were significantly higher in the recovered group compared to the control group.
These results indicate the antigenic nature of the truncated ORF2 protein and production of T helper type 1 cytokines.
Conclusion.
The truncated ORF2 protein can effectively induce significant cellular immune responsesand can be introduced as a potential vaccine candidate.
However, further studies are required to evaluate this protein in vivo.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Taherkhani, Reza& Farshadpour, Fatemeh& Makvandi, Manoochehr& Rajabi Memari, Hamid& Samarbafzadeh, Ali Reza& Sharifi, Nasrin…[et al.]. 2015. Cytokine Profiles and Cell Proliferation Responses to Truncated ORF2 Protein in Iranian Patients Recovered from Hepatitis E Infection. Journal of Tropical Medicine،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1070408
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Taherkhani, Reza…[et al.]. Cytokine Profiles and Cell Proliferation Responses to Truncated ORF2 Protein in Iranian Patients Recovered from Hepatitis E Infection. Journal of Tropical Medicine No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1070408
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Taherkhani, Reza& Farshadpour, Fatemeh& Makvandi, Manoochehr& Rajabi Memari, Hamid& Samarbafzadeh, Ali Reza& Sharifi, Nasrin…[et al.]. Cytokine Profiles and Cell Proliferation Responses to Truncated ORF2 Protein in Iranian Patients Recovered from Hepatitis E Infection. Journal of Tropical Medicine. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1070408
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1070408
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر