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Plasma Exchange for the Recurrence of Primary Focal Segmental Glomerulosclerosis in Adult Renal Transplant Recipients: A Meta-Analysis
المؤلفون المشاركون
Vlachopanos, Georgios
Georgalis, Argyrios
Gakiopoulou, Harikleia
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Posttransplant recurrence of primary focal segmental glomerulosclerosis (rFSGS) in the form of massive proteinuria is not uncommon and has detrimental consequences on renal allograft survival.
A putative circulating permeability factor has been implicated in the pathogenesis leading to widespread use of plasma exchange (PLEX).
We reviewed published studies to assess the role of PLEX on treatment of rFSGS in adults.
Methods.
Eligible manuscripts compared PLEX or variants with conventional care for inducing proteinuria remission (PR) in rFSGS and were identified through MEDLINE and reference lists.
Data were abstracted in parallel by two reviewers.
Results.
We detected 6 nonrandomized studies with 117 cases enrolled.
In a random effects model, the pooled risk ratio for the composite endpoint of partial or complete PR was 0,38 in favour of PLEX (95% CI: 0,23–0,61).
No statistical heterogeneity was observed among included studies (I2=0%, p = 0,42).
On average, 9–26 PLEX sessions were performed to achieve PR.
Renal allograft loss due to recurrence was lower (range: 0%–67%) in patients treated with PLEX.
Conclusion.
Notwithstanding the inherent limitations of small, observational trials, PLEX appears to be effective for PR in rFSGS.
Additional research is needed to further elucidate its optimal use and impact on long-term allograft survival.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vlachopanos, Georgios& Georgalis, Argyrios& Gakiopoulou, Harikleia. 2015. Plasma Exchange for the Recurrence of Primary Focal Segmental Glomerulosclerosis in Adult Renal Transplant Recipients: A Meta-Analysis. Journal of Transplantation،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1070437
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vlachopanos, Georgios…[et al.]. Plasma Exchange for the Recurrence of Primary Focal Segmental Glomerulosclerosis in Adult Renal Transplant Recipients: A Meta-Analysis. Journal of Transplantation No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1070437
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vlachopanos, Georgios& Georgalis, Argyrios& Gakiopoulou, Harikleia. Plasma Exchange for the Recurrence of Primary Focal Segmental Glomerulosclerosis in Adult Renal Transplant Recipients: A Meta-Analysis. Journal of Transplantation. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1070437
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1070437
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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