Plasma Exchange for the Recurrence of Primary Focal Segmental Glomerulosclerosis in Adult Renal Transplant Recipients: A Meta-Analysis
Joint Authors
Vlachopanos, Georgios
Georgalis, Argyrios
Gakiopoulou, Harikleia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Posttransplant recurrence of primary focal segmental glomerulosclerosis (rFSGS) in the form of massive proteinuria is not uncommon and has detrimental consequences on renal allograft survival.
A putative circulating permeability factor has been implicated in the pathogenesis leading to widespread use of plasma exchange (PLEX).
We reviewed published studies to assess the role of PLEX on treatment of rFSGS in adults.
Methods.
Eligible manuscripts compared PLEX or variants with conventional care for inducing proteinuria remission (PR) in rFSGS and were identified through MEDLINE and reference lists.
Data were abstracted in parallel by two reviewers.
Results.
We detected 6 nonrandomized studies with 117 cases enrolled.
In a random effects model, the pooled risk ratio for the composite endpoint of partial or complete PR was 0,38 in favour of PLEX (95% CI: 0,23–0,61).
No statistical heterogeneity was observed among included studies (I2=0%, p = 0,42).
On average, 9–26 PLEX sessions were performed to achieve PR.
Renal allograft loss due to recurrence was lower (range: 0%–67%) in patients treated with PLEX.
Conclusion.
Notwithstanding the inherent limitations of small, observational trials, PLEX appears to be effective for PR in rFSGS.
Additional research is needed to further elucidate its optimal use and impact on long-term allograft survival.
American Psychological Association (APA)
Vlachopanos, Georgios& Georgalis, Argyrios& Gakiopoulou, Harikleia. 2015. Plasma Exchange for the Recurrence of Primary Focal Segmental Glomerulosclerosis in Adult Renal Transplant Recipients: A Meta-Analysis. Journal of Transplantation،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1070437
Modern Language Association (MLA)
Vlachopanos, Georgios…[et al.]. Plasma Exchange for the Recurrence of Primary Focal Segmental Glomerulosclerosis in Adult Renal Transplant Recipients: A Meta-Analysis. Journal of Transplantation No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1070437
American Medical Association (AMA)
Vlachopanos, Georgios& Georgalis, Argyrios& Gakiopoulou, Harikleia. Plasma Exchange for the Recurrence of Primary Focal Segmental Glomerulosclerosis in Adult Renal Transplant Recipients: A Meta-Analysis. Journal of Transplantation. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1070437
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1070437