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Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease
المؤلفون المشاركون
Martins, Ralph N.
Verdile, Giuseppe
Keane, Kevin N.
Cruzat, Vinicius F.
Medic, Sandra
Sabale, Miheer
Rowles, Joanne
Wijesekara, Nadeeja
Fraser, Paul E.
Newsholme, Philip
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-26
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Type 2 diabetes (T2DM), Alzheimer’s disease (AD), and insulin resistance are age-related conditions and increased prevalence is of public concern.
Recent research has provided evidence that insulin resistance and impaired insulin signalling may be a contributory factor to the progression of diabetes, dementia, and other neurological disorders.
Alzheimer’s disease (AD) is the most common subtype of dementia.
Reduced release (for T2DM) and decreased action of insulin are central to the development and progression of both T2DM and AD.
A literature search was conducted to identify molecular commonalities between obesity, diabetes, and AD.
Insulin resistance affects many tissues and organs, either through impaired insulin signalling or through aberrant changes in both glucose and lipid (cholesterol and triacylglycerol) metabolism and concentrations in the blood.
Although epidemiological and biological evidence has highlighted an increased incidence of cognitive decline and AD in patients with T2DM, the common molecular basis of cell and tissue dysfunction is rapidly gaining recognition.
As a cause or consequence, the chronic inflammatory response and oxidative stress associated with T2DM, amyloid-β (Aβ) protein accumulation, and mitochondrial dysfunction link T2DM and AD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Verdile, Giuseppe& Keane, Kevin N.& Cruzat, Vinicius F.& Medic, Sandra& Sabale, Miheer& Rowles, Joanne…[et al.]. 2015. Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1070591
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Verdile, Giuseppe…[et al.]. Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease. Mediators of Inflammation No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1070591
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Verdile, Giuseppe& Keane, Kevin N.& Cruzat, Vinicius F.& Medic, Sandra& Sabale, Miheer& Rowles, Joanne…[et al.]. Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1070591
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1070591
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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