Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease
Joint Authors
Martins, Ralph N.
Verdile, Giuseppe
Keane, Kevin N.
Cruzat, Vinicius F.
Medic, Sandra
Sabale, Miheer
Rowles, Joanne
Wijesekara, Nadeeja
Fraser, Paul E.
Newsholme, Philip
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-26
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Type 2 diabetes (T2DM), Alzheimer’s disease (AD), and insulin resistance are age-related conditions and increased prevalence is of public concern.
Recent research has provided evidence that insulin resistance and impaired insulin signalling may be a contributory factor to the progression of diabetes, dementia, and other neurological disorders.
Alzheimer’s disease (AD) is the most common subtype of dementia.
Reduced release (for T2DM) and decreased action of insulin are central to the development and progression of both T2DM and AD.
A literature search was conducted to identify molecular commonalities between obesity, diabetes, and AD.
Insulin resistance affects many tissues and organs, either through impaired insulin signalling or through aberrant changes in both glucose and lipid (cholesterol and triacylglycerol) metabolism and concentrations in the blood.
Although epidemiological and biological evidence has highlighted an increased incidence of cognitive decline and AD in patients with T2DM, the common molecular basis of cell and tissue dysfunction is rapidly gaining recognition.
As a cause or consequence, the chronic inflammatory response and oxidative stress associated with T2DM, amyloid-β (Aβ) protein accumulation, and mitochondrial dysfunction link T2DM and AD.
American Psychological Association (APA)
Verdile, Giuseppe& Keane, Kevin N.& Cruzat, Vinicius F.& Medic, Sandra& Sabale, Miheer& Rowles, Joanne…[et al.]. 2015. Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1070591
Modern Language Association (MLA)
Verdile, Giuseppe…[et al.]. Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease. Mediators of Inflammation No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1070591
American Medical Association (AMA)
Verdile, Giuseppe& Keane, Kevin N.& Cruzat, Vinicius F.& Medic, Sandra& Sabale, Miheer& Rowles, Joanne…[et al.]. Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1070591
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1070591