Protective Effects of N-Acetylcysteine in Concanavalin A-Induced Hepatitis in Mice

المؤلفون المشاركون

Lu, Jie
Li, Jingjing
Wang, Junshan
Wang, Fan
Zhang, Huawei
Li, Sainan
Yin, Qin
Wang, Chengfen
Yang, Jing
Zheng, Yuanyuan
Xia, Yujing
Zhou, Ying-Qun
Chen, Kan
Zhu, Rong
Guo, Chuan-Yong
Weiqi, Dai

المصدر

Mediators of Inflammation

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-17، 17ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-03-02

دولة النشر

مصر

عدد الصفحات

17

التخصصات الرئيسية

الأمراض

الملخص EN

This study was designed to study the protective effects and mechanisms of N-acetylcysteine (NAC) in concanavalin A-induced hepatitis in mice.

In this study, pretreatment with NAC ameliorated the histopathological changes and suppressed inflammatory cytokines in ConA-induced hepatitis.

The expression of IL-2, IL-6, TNF-α, and IFN-γ was significantly reduced in the NAC-treated groups.

NAC activated PI3K/Akt pathway and inhibited the activation of NF-κB.

Additionally, NAC reduced autophagosome formation, as assessed by detecting the expression of LC3 and Beclin 1.

Our results demonstrate that NAC can alleviate ConA-induced hepatitis by regulating the PI3K/Akt pathway and reducing the late stages of autophagy.

Our results described a new pharmaceutical to provide more effective therapies for immune hepatitis.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Wang, Chengfen& Xia, Yujing& Zheng, Yuanyuan& Weiqi, Dai& Wang, Fan& Chen, Kan…[et al.]. 2015. Protective Effects of N-Acetylcysteine in Concanavalin A-Induced Hepatitis in Mice. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1072172

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Wang, Chengfen…[et al.]. Protective Effects of N-Acetylcysteine in Concanavalin A-Induced Hepatitis in Mice. Mediators of Inflammation No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1072172

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Wang, Chengfen& Xia, Yujing& Zheng, Yuanyuan& Weiqi, Dai& Wang, Fan& Chen, Kan…[et al.]. Protective Effects of N-Acetylcysteine in Concanavalin A-Induced Hepatitis in Mice. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1072172

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1072172