Protective Effects of N-Acetylcysteine in Concanavalin A-Induced Hepatitis in Mice
Joint Authors
Lu, Jie
Li, Jingjing
Wang, Junshan
Wang, Fan
Zhang, Huawei
Li, Sainan
Yin, Qin
Wang, Chengfen
Yang, Jing
Zheng, Yuanyuan
Xia, Yujing
Zhou, Ying-Qun
Chen, Kan
Zhu, Rong
Guo, Chuan-Yong
Weiqi, Dai
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-02
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
This study was designed to study the protective effects and mechanisms of N-acetylcysteine (NAC) in concanavalin A-induced hepatitis in mice.
In this study, pretreatment with NAC ameliorated the histopathological changes and suppressed inflammatory cytokines in ConA-induced hepatitis.
The expression of IL-2, IL-6, TNF-α, and IFN-γ was significantly reduced in the NAC-treated groups.
NAC activated PI3K/Akt pathway and inhibited the activation of NF-κB.
Additionally, NAC reduced autophagosome formation, as assessed by detecting the expression of LC3 and Beclin 1.
Our results demonstrate that NAC can alleviate ConA-induced hepatitis by regulating the PI3K/Akt pathway and reducing the late stages of autophagy.
Our results described a new pharmaceutical to provide more effective therapies for immune hepatitis.
American Psychological Association (APA)
Wang, Chengfen& Xia, Yujing& Zheng, Yuanyuan& Weiqi, Dai& Wang, Fan& Chen, Kan…[et al.]. 2015. Protective Effects of N-Acetylcysteine in Concanavalin A-Induced Hepatitis in Mice. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1072172
Modern Language Association (MLA)
Wang, Chengfen…[et al.]. Protective Effects of N-Acetylcysteine in Concanavalin A-Induced Hepatitis in Mice. Mediators of Inflammation No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1072172
American Medical Association (AMA)
Wang, Chengfen& Xia, Yujing& Zheng, Yuanyuan& Weiqi, Dai& Wang, Fan& Chen, Kan…[et al.]. Protective Effects of N-Acetylcysteine in Concanavalin A-Induced Hepatitis in Mice. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1072172
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072172