Expression and Function of Hypoxia Inducible Factor-1α and Vascular Endothelial Growth Factor in Pulp Tissue of Teeth under Orthodontic Movement
المؤلفون المشاركون
Wei, Fulan
Yang, Shuangyan
Xu, Hui
Guo, Qingyuan
Li, Qi
Hu, Lihua
Liu, Dongxu
Wang, Chunling
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-09-09
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Orthodontic force may lead to cell damage, circulatory disturbances, and vascular changes of the dental pulp, which make a hypoxic environment in pulp.
In order to maintain the homeostasis of dental pulp, hypoxia will inevitably induce the defensive reaction.
However, this is a complex process and is regulated by numerous factors.
In this study, we established an experimental animal model of orthodontic tooth movement to investigate the effects of mechanical force on the expression of VEGF and HIF-1α in dental pulp.
Histological analysis of dental pulp and expressions of HIF-1α and VEGF proteins in dental pulp were examined.
The results showed that inflammation and vascular changes happened in dental pulp tissue in different periods.
Additionally, there were significant changes in the expression of HIF-1α and VEGF proteins under orthodontic force.
After application of mechanical load, expression of HIF-1α and VEGF was markedly positive in 1, 3, 7 d, and 2 w groups, and then it weakened in 4 w group.
These findings suggested that the expression of HIF-1α and VEGF was enhanced by mechanical force.
HIF-1α and VEGF may play an important role in retaining the homeostasis of dental pulp during orthodontic tooth movement.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wei, Fulan& Yang, Shuangyan& Xu, Hui& Guo, Qingyuan& Li, Qi& Hu, Lihua…[et al.]. 2015. Expression and Function of Hypoxia Inducible Factor-1α and Vascular Endothelial Growth Factor in Pulp Tissue of Teeth under Orthodontic Movement. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072188
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wei, Fulan…[et al.]. Expression and Function of Hypoxia Inducible Factor-1α and Vascular Endothelial Growth Factor in Pulp Tissue of Teeth under Orthodontic Movement. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072188
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wei, Fulan& Yang, Shuangyan& Xu, Hui& Guo, Qingyuan& Li, Qi& Hu, Lihua…[et al.]. Expression and Function of Hypoxia Inducible Factor-1α and Vascular Endothelial Growth Factor in Pulp Tissue of Teeth under Orthodontic Movement. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072188
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072188
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر