Expression and Function of Hypoxia Inducible Factor-1α and Vascular Endothelial Growth Factor in Pulp Tissue of Teeth under Orthodontic Movement
Joint Authors
Wei, Fulan
Yang, Shuangyan
Xu, Hui
Guo, Qingyuan
Li, Qi
Hu, Lihua
Liu, Dongxu
Wang, Chunling
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Orthodontic force may lead to cell damage, circulatory disturbances, and vascular changes of the dental pulp, which make a hypoxic environment in pulp.
In order to maintain the homeostasis of dental pulp, hypoxia will inevitably induce the defensive reaction.
However, this is a complex process and is regulated by numerous factors.
In this study, we established an experimental animal model of orthodontic tooth movement to investigate the effects of mechanical force on the expression of VEGF and HIF-1α in dental pulp.
Histological analysis of dental pulp and expressions of HIF-1α and VEGF proteins in dental pulp were examined.
The results showed that inflammation and vascular changes happened in dental pulp tissue in different periods.
Additionally, there were significant changes in the expression of HIF-1α and VEGF proteins under orthodontic force.
After application of mechanical load, expression of HIF-1α and VEGF was markedly positive in 1, 3, 7 d, and 2 w groups, and then it weakened in 4 w group.
These findings suggested that the expression of HIF-1α and VEGF was enhanced by mechanical force.
HIF-1α and VEGF may play an important role in retaining the homeostasis of dental pulp during orthodontic tooth movement.
American Psychological Association (APA)
Wei, Fulan& Yang, Shuangyan& Xu, Hui& Guo, Qingyuan& Li, Qi& Hu, Lihua…[et al.]. 2015. Expression and Function of Hypoxia Inducible Factor-1α and Vascular Endothelial Growth Factor in Pulp Tissue of Teeth under Orthodontic Movement. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072188
Modern Language Association (MLA)
Wei, Fulan…[et al.]. Expression and Function of Hypoxia Inducible Factor-1α and Vascular Endothelial Growth Factor in Pulp Tissue of Teeth under Orthodontic Movement. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072188
American Medical Association (AMA)
Wei, Fulan& Yang, Shuangyan& Xu, Hui& Guo, Qingyuan& Li, Qi& Hu, Lihua…[et al.]. Expression and Function of Hypoxia Inducible Factor-1α and Vascular Endothelial Growth Factor in Pulp Tissue of Teeth under Orthodontic Movement. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072188
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072188