Dengue Virus Infection Causes the Activation of Distinct NF-κB Pathways for Inducible Nitric Oxide Synthase and TNF-α Expression in RAW264.7 Cells
المؤلفون المشاركون
Lin, Yee-Shin
Cheng, Yi-Lin
Wan, Shu-Wen
Ou, Yi-Dan
Yu, Chia-Yi
Tsai, Tsung-Ting
Tseng, Po-Chun
Lin, Chiou-Feng
Chen, Chia-Ling
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-14
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Infection with dengue virus (DENV) causes an increase in proinflammatory responses, such as nitric oxide (NO) generation and TNF-α expression; however, the molecular mechanism underlying this inflammatory activation remains undefined, although the activation of the transcription factor NF-κB is generally involved.
In addition to TNF-α production in DENV-infected murine macrophage RAW264.7 cells, inducible NO synthase was transcriptionally and posttranslationally elevated and accompanied by NO generation.
NF-κB is known to be activated by DENV infection.
Pharmacologically inhibiting NF-κB activation abolishes iNOS/NO biosynthesis and TNF-α production.
With inhibition, the potential role of NF-κB in oxidative signaling regulation was prevented during DENV infection.
Heat-inactivated DENV failed to cause the identified inflammatory responses.
Pharmacological inhibition of TLR3 partly decreased NF-κB activation; however, it effectively abolished inducible iNOS/NO biosynthesis but did not inhibit TNF-α production.
In contrast to TLR3, viral protein NS2B3 also independently contributed to NF-κB activation to regulate TNF-α production.
These results show the distinct pathways for NF-κB activation caused by DENV infection individually for the regulation of iNOS/NO and TNF-α expression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cheng, Yi-Lin& Lin, Yee-Shin& Chen, Chia-Ling& Wan, Shu-Wen& Ou, Yi-Dan& Yu, Chia-Yi…[et al.]. 2015. Dengue Virus Infection Causes the Activation of Distinct NF-κB Pathways for Inducible Nitric Oxide Synthase and TNF-α Expression in RAW264.7 Cells. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1072222
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cheng, Yi-Lin…[et al.]. Dengue Virus Infection Causes the Activation of Distinct NF-κB Pathways for Inducible Nitric Oxide Synthase and TNF-α Expression in RAW264.7 Cells. Mediators of Inflammation No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1072222
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cheng, Yi-Lin& Lin, Yee-Shin& Chen, Chia-Ling& Wan, Shu-Wen& Ou, Yi-Dan& Yu, Chia-Yi…[et al.]. Dengue Virus Infection Causes the Activation of Distinct NF-κB Pathways for Inducible Nitric Oxide Synthase and TNF-α Expression in RAW264.7 Cells. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1072222
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072222
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر