Enterococcus faecium NCIMB 10415 Modulates Epithelial Integrity, Heat Shock Protein, and Proinflammatory Cytokine Response in Intestinal Cells
المؤلفون المشاركون
Klingspor, Shanti
Bondzio, Angelika
Martens, Holger
Aschenbach, Jörg R.
Bratz, Katharina
Tedin, Karsten
Einspanier, Ralf
Lodemann, Ulrike
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-08
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Probiotics have shown positive effects on gastrointestinal diseases; they have barrier-modulating effects and change the inflammatory response towards pathogens in studies in vitro.
The aim of this investigation has been to examine the response of intestinal epithelial cells to Enterococcus faecium NCIMB 10415 (E.
faecium), a probiotic positively affecting diarrhea incidence in piglets, and two pathogenic Escherichia coli (E.
coli) strains, with specific focus on the probiotic modulation of the response to the pathogenic challenge.
Porcine (IPEC-J2) and human (Caco-2) intestinal cells were incubated without bacteria (control), with E.
faecium, with enteropathogenic (EPEC) or enterotoxigenic E.
coli (ETEC) each alone or in combination with E.
faecium.
The ETEC strain decreased transepithelial resistance (TER) and increased IL-8 mRNA and protein expression in both cell lines compared with control cells, an effect that could be prevented by pre- and coincubation with E.
faecium.
Similar effects were observed for the increased expression of heat shock protein 70 in Caco-2 cells.
When the cells were challenged by the EPEC strain, no such pattern of changes could be observed.
The reduced decrease in TER and the reduction of the proinflammatory and stress response of enterocytes following pathogenic challenge indicate the protective effect of the probiotic.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Klingspor, Shanti& Bondzio, Angelika& Martens, Holger& Aschenbach, Jörg R.& Bratz, Katharina& Tedin, Karsten…[et al.]. 2015. Enterococcus faecium NCIMB 10415 Modulates Epithelial Integrity, Heat Shock Protein, and Proinflammatory Cytokine Response in Intestinal Cells. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072241
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Klingspor, Shanti…[et al.]. Enterococcus faecium NCIMB 10415 Modulates Epithelial Integrity, Heat Shock Protein, and Proinflammatory Cytokine Response in Intestinal Cells. Mediators of Inflammation No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1072241
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Klingspor, Shanti& Bondzio, Angelika& Martens, Holger& Aschenbach, Jörg R.& Bratz, Katharina& Tedin, Karsten…[et al.]. Enterococcus faecium NCIMB 10415 Modulates Epithelial Integrity, Heat Shock Protein, and Proinflammatory Cytokine Response in Intestinal Cells. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072241
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072241
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر