Effect of TLR4MyD88 Signaling Pathway on Expression of IL-1 β and TNF- α in Synovial Fibroblasts from Temporomandibular Joint Exposed to Lipopolysaccharide
المؤلفون المشاركون
Lin, Xuefen
Kong, Jingjing
Wu, Qingting
Yang, Yingying
Ji, Ping
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-24
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Accumulating evidence from previous studies suggested that interleukin-1 (IL-1β) and tumor necrosis factor-α (TNF-α) play an important role in pathogenesis of temporomandibular disorders (TMD).
However, the cell surface receptors and the intracellular signal pathways leading to these cytokines expression are not fully understood.
In the current study, we investigated the roles of Toll-like receptor 4 (TLR4) and its adaptor myeloid differentiation factor 88 (MyD88) in the expression of IL-1β and TNF-α in synovial fibroblasts (SFs) separated from rat temporomandibular joint (TMJ) with lipopolysaccharide (LPS) stimulation.
The results showed that treatment with LPS could increase TLR4, MyD88, IL-1β, and TNF-α expression at both mRNA and protein levels.
In addition, increased expression of IL-1β and TNF-α could be blocked by treatment with TAK-242, a blocker of TLR4 signaling, and also by MyD88 inhibitory peptide (MIP).
These findings suggested that maybe TLR4/MyD88 signal transduction pathway participates in enhanced expression of IL-1 and TNF-α in patients with TMD.
The activation of TLR4/MyD88 signal transduction pathway which results in production of proinflammatory factors may play a role in the pathogenesis of TMD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Xuefen& Kong, Jingjing& Wu, Qingting& Yang, Yingying& Ji, Ping. 2015. Effect of TLR4MyD88 Signaling Pathway on Expression of IL-1 β and TNF- α in Synovial Fibroblasts from Temporomandibular Joint Exposed to Lipopolysaccharide. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072251
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Xuefen…[et al.]. Effect of TLR4MyD88 Signaling Pathway on Expression of IL-1 β and TNF- α in Synovial Fibroblasts from Temporomandibular Joint Exposed to Lipopolysaccharide. Mediators of Inflammation No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1072251
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Xuefen& Kong, Jingjing& Wu, Qingting& Yang, Yingying& Ji, Ping. Effect of TLR4MyD88 Signaling Pathway on Expression of IL-1 β and TNF- α in Synovial Fibroblasts from Temporomandibular Joint Exposed to Lipopolysaccharide. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072251
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072251
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر