Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhibition of Inflammatory Cytokines in Patients with Rheumatoid Arthritis
المؤلفون المشاركون
He, Dong-Yi
Xu, Yunzhi
Zhu, Qi
Song, Jinglve
Liu, Hongli
Miao, Yutong
Yang, Fan
Wang, Feiyan
Cheng, Wenjing
Xi, Yebin
Chen, Guangjie
Niu, Xiaoyin
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-02
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Objective.
To expand upon the role of iguratimod (T-614) in the treatment of rheumatoid arthritis (RA), we investigated whether the Th1, Th17, follicular helper T cells (Tfh), and regulatory T cells (Treg) imbalance could be reversed by iguratimod and the clinical implications of this reversal.
Methods.
In this trial, 74 patients were randomized into iguratimod-treated (group A) and control (broup B) group for a 24-week treatment period.
In the subsequent 28 weeks, both groups were given iguratimod.
Frequencies of Th1, Th17, Tfh, and Treg were quantified using flow cytometry, and serum cytokines were detected by enzyme-linked immunosorbent assay.
mRNA expression of cytokines and transcriptional factor were quantified by RT-PCR.
The composite Disease Activity Score, erythrocyte sedimentation rate, and C-reactive protein were assessed at each visit.
Result.
The clinical scores demonstrated effective suppression of disease after treatment with iguratimod.
In addition, iguratimod downregulated Th1, Th17-type response and upregulated Treg.
Furthermore, the levels of Th1, Th17, and Tfh associated inflammatory cytokines and transcription factors were reduced after treatment with iguratimod, while the levels of Treg associated cytokines and transcription factors were increased.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Yunzhi& Zhu, Qi& Song, Jinglve& Liu, Hongli& Miao, Yutong& Yang, Fan…[et al.]. 2015. Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhibition of Inflammatory Cytokines in Patients with Rheumatoid Arthritis. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1072266
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Yunzhi…[et al.]. Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhibition of Inflammatory Cytokines in Patients with Rheumatoid Arthritis. Mediators of Inflammation No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1072266
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Yunzhi& Zhu, Qi& Song, Jinglve& Liu, Hongli& Miao, Yutong& Yang, Fan…[et al.]. Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhibition of Inflammatory Cytokines in Patients with Rheumatoid Arthritis. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1072266
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072266
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر