Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhibition of Inflammatory Cytokines in Patients with Rheumatoid Arthritis
Joint Authors
He, Dong-Yi
Xu, Yunzhi
Zhu, Qi
Song, Jinglve
Liu, Hongli
Miao, Yutong
Yang, Fan
Wang, Feiyan
Cheng, Wenjing
Xi, Yebin
Chen, Guangjie
Niu, Xiaoyin
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-02
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Objective.
To expand upon the role of iguratimod (T-614) in the treatment of rheumatoid arthritis (RA), we investigated whether the Th1, Th17, follicular helper T cells (Tfh), and regulatory T cells (Treg) imbalance could be reversed by iguratimod and the clinical implications of this reversal.
Methods.
In this trial, 74 patients were randomized into iguratimod-treated (group A) and control (broup B) group for a 24-week treatment period.
In the subsequent 28 weeks, both groups were given iguratimod.
Frequencies of Th1, Th17, Tfh, and Treg were quantified using flow cytometry, and serum cytokines were detected by enzyme-linked immunosorbent assay.
mRNA expression of cytokines and transcriptional factor were quantified by RT-PCR.
The composite Disease Activity Score, erythrocyte sedimentation rate, and C-reactive protein were assessed at each visit.
Result.
The clinical scores demonstrated effective suppression of disease after treatment with iguratimod.
In addition, iguratimod downregulated Th1, Th17-type response and upregulated Treg.
Furthermore, the levels of Th1, Th17, and Tfh associated inflammatory cytokines and transcription factors were reduced after treatment with iguratimod, while the levels of Treg associated cytokines and transcription factors were increased.
American Psychological Association (APA)
Xu, Yunzhi& Zhu, Qi& Song, Jinglve& Liu, Hongli& Miao, Yutong& Yang, Fan…[et al.]. 2015. Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhibition of Inflammatory Cytokines in Patients with Rheumatoid Arthritis. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1072266
Modern Language Association (MLA)
Xu, Yunzhi…[et al.]. Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhibition of Inflammatory Cytokines in Patients with Rheumatoid Arthritis. Mediators of Inflammation No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1072266
American Medical Association (AMA)
Xu, Yunzhi& Zhu, Qi& Song, Jinglve& Liu, Hongli& Miao, Yutong& Yang, Fan…[et al.]. Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhibition of Inflammatory Cytokines in Patients with Rheumatoid Arthritis. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1072266
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072266