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Decreased Regulatory T Cells in Vulnerable Atherosclerotic Lesions: Imbalance between Pro- and Anti-Inflammatory Cells in Atherosclerosis
المؤلفون المشاركون
Figulla, Hans Reiner
Rohm, Ilonka
Atiskova, Yevgeniya
Drobnik, Stefanie
Kretzschmar, Daniel
Pistulli, Rudin
Zanow, Jürgen
Krönert, Thomas
Mall, Gita
Yilmaz, Atilla
Fritzenwanger, Michael
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-01-15
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Atherosclerosis is a chronic inflammatory disease of the arterial wall in which presentation of autoantigens by dendritic cells (DCs) leads to the activation of T cells.
Anti-inflammatory cells like Tregs counterbalance inflammation in atherogenesis.
In our study, human carotid plaque specimens were classified as stable (14) and unstable (15) according to established morphological criteria.
Vessel specimens (n=12) without any signs of atherosclerosis were used as controls.
Immunohistochemical staining was performed to detect different types of DCs (S100, fascin, CD83, CD209, CD304, and CD123), proinflammatory T cells (CD3, CD4, CD8, and CD161), and anti-inflammatory Tregs (FoxP3).
The following results were observed: in unstable lesions, significantly higher numbers of proinflammatory cells like DCs, T helper cells, cytotoxic T cells, and natural killer cells were detected compared to stable plaques.
Additionally, there was a significantly higher expression of HLA-DR and more T cell activation (CD25, CD69) in unstable lesions.
On the contrary, unstable lesions contained significantly lower numbers of Tregs.
Furthermore, a significant inverse correlation between myeloid DCs and Tregs was shown.
These data suggest an increased inflammatory state in vulnerable plaques resulting from an imbalance of the frequency of local pro- and anti-inflammatory immune cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rohm, Ilonka& Atiskova, Yevgeniya& Drobnik, Stefanie& Fritzenwanger, Michael& Kretzschmar, Daniel& Pistulli, Rudin…[et al.]. 2015. Decreased Regulatory T Cells in Vulnerable Atherosclerotic Lesions: Imbalance between Pro- and Anti-Inflammatory Cells in Atherosclerosis. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1072272
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rohm, Ilonka…[et al.]. Decreased Regulatory T Cells in Vulnerable Atherosclerotic Lesions: Imbalance between Pro- and Anti-Inflammatory Cells in Atherosclerosis. Mediators of Inflammation No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1072272
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rohm, Ilonka& Atiskova, Yevgeniya& Drobnik, Stefanie& Fritzenwanger, Michael& Kretzschmar, Daniel& Pistulli, Rudin…[et al.]. Decreased Regulatory T Cells in Vulnerable Atherosclerotic Lesions: Imbalance between Pro- and Anti-Inflammatory Cells in Atherosclerosis. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1072272
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072272
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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