Decreased Regulatory T Cells in Vulnerable Atherosclerotic Lesions: Imbalance between Pro- and Anti-Inflammatory Cells in Atherosclerosis
Joint Authors
Figulla, Hans Reiner
Rohm, Ilonka
Atiskova, Yevgeniya
Drobnik, Stefanie
Kretzschmar, Daniel
Pistulli, Rudin
Zanow, Jürgen
Krönert, Thomas
Mall, Gita
Yilmaz, Atilla
Fritzenwanger, Michael
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-01-15
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Atherosclerosis is a chronic inflammatory disease of the arterial wall in which presentation of autoantigens by dendritic cells (DCs) leads to the activation of T cells.
Anti-inflammatory cells like Tregs counterbalance inflammation in atherogenesis.
In our study, human carotid plaque specimens were classified as stable (14) and unstable (15) according to established morphological criteria.
Vessel specimens (n=12) without any signs of atherosclerosis were used as controls.
Immunohistochemical staining was performed to detect different types of DCs (S100, fascin, CD83, CD209, CD304, and CD123), proinflammatory T cells (CD3, CD4, CD8, and CD161), and anti-inflammatory Tregs (FoxP3).
The following results were observed: in unstable lesions, significantly higher numbers of proinflammatory cells like DCs, T helper cells, cytotoxic T cells, and natural killer cells were detected compared to stable plaques.
Additionally, there was a significantly higher expression of HLA-DR and more T cell activation (CD25, CD69) in unstable lesions.
On the contrary, unstable lesions contained significantly lower numbers of Tregs.
Furthermore, a significant inverse correlation between myeloid DCs and Tregs was shown.
These data suggest an increased inflammatory state in vulnerable plaques resulting from an imbalance of the frequency of local pro- and anti-inflammatory immune cells.
American Psychological Association (APA)
Rohm, Ilonka& Atiskova, Yevgeniya& Drobnik, Stefanie& Fritzenwanger, Michael& Kretzschmar, Daniel& Pistulli, Rudin…[et al.]. 2015. Decreased Regulatory T Cells in Vulnerable Atherosclerotic Lesions: Imbalance between Pro- and Anti-Inflammatory Cells in Atherosclerosis. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1072272
Modern Language Association (MLA)
Rohm, Ilonka…[et al.]. Decreased Regulatory T Cells in Vulnerable Atherosclerotic Lesions: Imbalance between Pro- and Anti-Inflammatory Cells in Atherosclerosis. Mediators of Inflammation No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1072272
American Medical Association (AMA)
Rohm, Ilonka& Atiskova, Yevgeniya& Drobnik, Stefanie& Fritzenwanger, Michael& Kretzschmar, Daniel& Pistulli, Rudin…[et al.]. Decreased Regulatory T Cells in Vulnerable Atherosclerotic Lesions: Imbalance between Pro- and Anti-Inflammatory Cells in Atherosclerosis. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1072272
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072272