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Secretion of One Adipokine NamptVisfatin Suppresses the Inflammatory Stress-Induced NF-κB Activity and Affects Nampt-Dependent Cell Viability in Huh-7 Cells
المؤلفون المشاركون
Pan, Shwu-Fen
Lin, Yi-Ching
Wu, Hui-Chung
Liao, Chen-Chung
Chou, Yi-Chih
Chiu, Chi-Ming
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-26
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Nampt/visfatin acts in both intracellular and extracellular compartments to regulate multiple biological roles, including NAD metabolism, cancer, inflammation, and senescence.
However, its function in chronic inflammation and carcinogenesis in hepatocellular carcinoma (HCC) has not been well-defined.
Here we use Huh-7 hepatoma cells as a model to determine how Nampt/visfatin affects cellular survival under oxidative stress.
We found that the transition of Nampt/visfatin from intracellular into extracellular form was induced by H2O2 treatment in 293T cells and confirmed that this phenomenon was not due to cell death but through the secretion of Nampt/visfatin.
In addition, Nampt/visfatin suppressed cell viability in oxidative treatment in Huh-7 cells and acted on the inhibition of hepatoma cell growth.
Oxidative stress also reduced the Nampt-mediated activation of NF-κB gene expression.
In this study, we identify a novel feature of Nampt/visfatin which functions as an adipokine that can be secreted upon cellular stress.
Our results provide an example to understand how adipokine interacts with chemotherapeutic treatment by oxidative stress in HCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Yi-Ching& Wu, Hui-Chung& Liao, Chen-Chung& Chou, Yi-Chih& Pan, Shwu-Fen& Chiu, Chi-Ming. 2015. Secretion of One Adipokine NamptVisfatin Suppresses the Inflammatory Stress-Induced NF-κB Activity and Affects Nampt-Dependent Cell Viability in Huh-7 Cells. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072301
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Yi-Ching…[et al.]. Secretion of One Adipokine NamptVisfatin Suppresses the Inflammatory Stress-Induced NF-κB Activity and Affects Nampt-Dependent Cell Viability in Huh-7 Cells. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072301
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Yi-Ching& Wu, Hui-Chung& Liao, Chen-Chung& Chou, Yi-Chih& Pan, Shwu-Fen& Chiu, Chi-Ming. Secretion of One Adipokine NamptVisfatin Suppresses the Inflammatory Stress-Induced NF-κB Activity and Affects Nampt-Dependent Cell Viability in Huh-7 Cells. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072301
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072301
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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