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Secretion of One Adipokine NamptVisfatin Suppresses the Inflammatory Stress-Induced NF-κB Activity and Affects Nampt-Dependent Cell Viability in Huh-7 Cells
Joint Authors
Pan, Shwu-Fen
Lin, Yi-Ching
Wu, Hui-Chung
Liao, Chen-Chung
Chou, Yi-Chih
Chiu, Chi-Ming
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Nampt/visfatin acts in both intracellular and extracellular compartments to regulate multiple biological roles, including NAD metabolism, cancer, inflammation, and senescence.
However, its function in chronic inflammation and carcinogenesis in hepatocellular carcinoma (HCC) has not been well-defined.
Here we use Huh-7 hepatoma cells as a model to determine how Nampt/visfatin affects cellular survival under oxidative stress.
We found that the transition of Nampt/visfatin from intracellular into extracellular form was induced by H2O2 treatment in 293T cells and confirmed that this phenomenon was not due to cell death but through the secretion of Nampt/visfatin.
In addition, Nampt/visfatin suppressed cell viability in oxidative treatment in Huh-7 cells and acted on the inhibition of hepatoma cell growth.
Oxidative stress also reduced the Nampt-mediated activation of NF-κB gene expression.
In this study, we identify a novel feature of Nampt/visfatin which functions as an adipokine that can be secreted upon cellular stress.
Our results provide an example to understand how adipokine interacts with chemotherapeutic treatment by oxidative stress in HCC.
American Psychological Association (APA)
Lin, Yi-Ching& Wu, Hui-Chung& Liao, Chen-Chung& Chou, Yi-Chih& Pan, Shwu-Fen& Chiu, Chi-Ming. 2015. Secretion of One Adipokine NamptVisfatin Suppresses the Inflammatory Stress-Induced NF-κB Activity and Affects Nampt-Dependent Cell Viability in Huh-7 Cells. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072301
Modern Language Association (MLA)
Lin, Yi-Ching…[et al.]. Secretion of One Adipokine NamptVisfatin Suppresses the Inflammatory Stress-Induced NF-κB Activity and Affects Nampt-Dependent Cell Viability in Huh-7 Cells. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072301
American Medical Association (AMA)
Lin, Yi-Ching& Wu, Hui-Chung& Liao, Chen-Chung& Chou, Yi-Chih& Pan, Shwu-Fen& Chiu, Chi-Ming. Secretion of One Adipokine NamptVisfatin Suppresses the Inflammatory Stress-Induced NF-κB Activity and Affects Nampt-Dependent Cell Viability in Huh-7 Cells. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072301
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072301