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Inflammation as a Keystone of Bone Marrow Stroma Alterations in Primary Myelofibrosis
المؤلفون المشاركون
Desterke, Christophe
Martinaud, Christophe
Ruzehaji, Nadira
Le Bousse-Kerdilès, Marie-Caroline
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-12
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Primary myelofibrosis (PMF) is a clonal myeloproliferative neoplasm where severity as well as treatment complexity is mainly attributed to a long lasting disease and presence of bone marrow stroma alterations as evidenced by myelofibrosis, neoangiogenesis, and osteosclerosis.
While recent understanding of mutations role in hematopoietic cells provides an explanation for pathological myeloproliferation, functional involvement of stromal cells in the disease pathogenesis remains poorly understood.
The current dogma is that stromal changes are secondary to the cytokine “storm” produced by the hematopoietic clone cells.
However, despite therapies targeting the myeloproliferation-sustaining clones, PMF is still regarded as an incurable disease except for patients, who are successful recipients of allogeneic stem cell transplantation.
Although the clinical benefits of these inhibitors have been correlated with a marked reduction in serum proinflammatory cytokines produced by the hematopoietic clones, further demonstrating the importance of inflammation in the pathological process, these treatments do not address the role of the altered bone marrow stroma in the pathological process.
In this review, we propose hypotheses suggesting that the stroma is inflammatory-imprinted by clonal hematopoietic cells up to a point where it becomes “independent” of hematopoietic cell stimulation, resulting in an inflammatory vicious circle requiring combined stroma targeted therapies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Desterke, Christophe& Martinaud, Christophe& Ruzehaji, Nadira& Le Bousse-Kerdilès, Marie-Caroline. 2015. Inflammation as a Keystone of Bone Marrow Stroma Alterations in Primary Myelofibrosis. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1072315
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Desterke, Christophe…[et al.]. Inflammation as a Keystone of Bone Marrow Stroma Alterations in Primary Myelofibrosis. Mediators of Inflammation No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1072315
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Desterke, Christophe& Martinaud, Christophe& Ruzehaji, Nadira& Le Bousse-Kerdilès, Marie-Caroline. Inflammation as a Keystone of Bone Marrow Stroma Alterations in Primary Myelofibrosis. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1072315
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072315
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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