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Inflammation as a Keystone of Bone Marrow Stroma Alterations in Primary Myelofibrosis
Joint Authors
Desterke, Christophe
Martinaud, Christophe
Ruzehaji, Nadira
Le Bousse-Kerdilès, Marie-Caroline
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-12
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Primary myelofibrosis (PMF) is a clonal myeloproliferative neoplasm where severity as well as treatment complexity is mainly attributed to a long lasting disease and presence of bone marrow stroma alterations as evidenced by myelofibrosis, neoangiogenesis, and osteosclerosis.
While recent understanding of mutations role in hematopoietic cells provides an explanation for pathological myeloproliferation, functional involvement of stromal cells in the disease pathogenesis remains poorly understood.
The current dogma is that stromal changes are secondary to the cytokine “storm” produced by the hematopoietic clone cells.
However, despite therapies targeting the myeloproliferation-sustaining clones, PMF is still regarded as an incurable disease except for patients, who are successful recipients of allogeneic stem cell transplantation.
Although the clinical benefits of these inhibitors have been correlated with a marked reduction in serum proinflammatory cytokines produced by the hematopoietic clones, further demonstrating the importance of inflammation in the pathological process, these treatments do not address the role of the altered bone marrow stroma in the pathological process.
In this review, we propose hypotheses suggesting that the stroma is inflammatory-imprinted by clonal hematopoietic cells up to a point where it becomes “independent” of hematopoietic cell stimulation, resulting in an inflammatory vicious circle requiring combined stroma targeted therapies.
American Psychological Association (APA)
Desterke, Christophe& Martinaud, Christophe& Ruzehaji, Nadira& Le Bousse-Kerdilès, Marie-Caroline. 2015. Inflammation as a Keystone of Bone Marrow Stroma Alterations in Primary Myelofibrosis. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1072315
Modern Language Association (MLA)
Desterke, Christophe…[et al.]. Inflammation as a Keystone of Bone Marrow Stroma Alterations in Primary Myelofibrosis. Mediators of Inflammation No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1072315
American Medical Association (AMA)
Desterke, Christophe& Martinaud, Christophe& Ruzehaji, Nadira& Le Bousse-Kerdilès, Marie-Caroline. Inflammation as a Keystone of Bone Marrow Stroma Alterations in Primary Myelofibrosis. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1072315
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072315