Effect of Negative Pressure Therapy on the Inflammatory Response of the Intestinal Microenvironment in a Porcine Septic Model
المؤلفون المشاركون
Norbury, Kenneth C.
Moyer, Mary Pat
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-30
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
In a swine model of ischemia/reperfusion injury coupled with sepsis, we have previously shown attenuation of secondary organ injury and decreased mortality with negative pressure therapy (NPT).
We hypothesized that NPT modulates the intestinal microenvironment by mediating the innate immune system.
Sepsis was induced in 12 anesthetized female pigs.
Group 1 ( n = 6 ) was decompressed at 12 hrs after injury ( T 12 ) and treated with standard of care (SOC), and group 2 ( n = 6 ) with NPT for up to T 48 .
Immunoparalysis was evident as lymphocytopenia at T 24 in both groups; however, survival was improved in the NPT group versus SOC (Odds ratio = 4.0).
The SOC group showed significant reduction in lymphocyte numbers compared to NPT group by T 48 ( p < 0.05 ).
The capacity of peritoneal fluid to stimulate a robust reactive oxygen species response in vitro was greater for the NPT group, peaking at T 24 for both M1 ( p = 0.0197 ) and M2 macrophages ( p = 0.085 ).
Plasma elicited little if any effect which was confirmed by microarray analysis.
In this septic swine model NPT appeared to modulate the intestinal microenvironment, facilitating an early robust, yet transient, host defense mediated by M1 and M2 macrophages.
NPT may help overcome immunoparalysis that occurs during inflammatory response to septic injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Norbury, Kenneth C.& Moyer, Mary Pat. 2015. Effect of Negative Pressure Therapy on the Inflammatory Response of the Intestinal Microenvironment in a Porcine Septic Model. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072321
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Norbury, Kenneth C.& Moyer, Mary Pat. Effect of Negative Pressure Therapy on the Inflammatory Response of the Intestinal Microenvironment in a Porcine Septic Model. Mediators of Inflammation No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1072321
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Norbury, Kenneth C.& Moyer, Mary Pat. Effect of Negative Pressure Therapy on the Inflammatory Response of the Intestinal Microenvironment in a Porcine Septic Model. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072321
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072321
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر