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Effect of Negative Pressure Therapy on the Inflammatory Response of the Intestinal Microenvironment in a Porcine Septic Model
Joint Authors
Norbury, Kenneth C.
Moyer, Mary Pat
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In a swine model of ischemia/reperfusion injury coupled with sepsis, we have previously shown attenuation of secondary organ injury and decreased mortality with negative pressure therapy (NPT).
We hypothesized that NPT modulates the intestinal microenvironment by mediating the innate immune system.
Sepsis was induced in 12 anesthetized female pigs.
Group 1 ( n = 6 ) was decompressed at 12 hrs after injury ( T 12 ) and treated with standard of care (SOC), and group 2 ( n = 6 ) with NPT for up to T 48 .
Immunoparalysis was evident as lymphocytopenia at T 24 in both groups; however, survival was improved in the NPT group versus SOC (Odds ratio = 4.0).
The SOC group showed significant reduction in lymphocyte numbers compared to NPT group by T 48 ( p < 0.05 ).
The capacity of peritoneal fluid to stimulate a robust reactive oxygen species response in vitro was greater for the NPT group, peaking at T 24 for both M1 ( p = 0.0197 ) and M2 macrophages ( p = 0.085 ).
Plasma elicited little if any effect which was confirmed by microarray analysis.
In this septic swine model NPT appeared to modulate the intestinal microenvironment, facilitating an early robust, yet transient, host defense mediated by M1 and M2 macrophages.
NPT may help overcome immunoparalysis that occurs during inflammatory response to septic injury.
American Psychological Association (APA)
Norbury, Kenneth C.& Moyer, Mary Pat. 2015. Effect of Negative Pressure Therapy on the Inflammatory Response of the Intestinal Microenvironment in a Porcine Septic Model. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072321
Modern Language Association (MLA)
Norbury, Kenneth C.& Moyer, Mary Pat. Effect of Negative Pressure Therapy on the Inflammatory Response of the Intestinal Microenvironment in a Porcine Septic Model. Mediators of Inflammation No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1072321
American Medical Association (AMA)
Norbury, Kenneth C.& Moyer, Mary Pat. Effect of Negative Pressure Therapy on the Inflammatory Response of the Intestinal Microenvironment in a Porcine Septic Model. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072321
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072321