![](/images/graphics-bg.png)
Nerve Blockage Attenuates Postoperative Inflammation in Hippocampus of Young Rat Model with Surgical Trauma
المؤلفون المشاركون
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-19
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
It is hypothesized that central nervous system inflammation induced by systematic inflammation due to surgical trauma plays a critical role in postoperative cognitive dysfunction.
The potential inhibitory effect of nerve blockage with local anesthetics on peripheral inflammatory response has been reported.
We hypothesize that nerve blockage may be effective in reducing postoperative inflammation and cognitive decline.
The rats at the age of 4 weeks were subjected to general anesthesia and humeral fracture fixation, in combination with brachial plexus block, saline versus ropivacaine, respectively.
The rats from control group underwent general anesthesia only.
The expression of proinflammatory cytokines in plasma and in hippocampus was measured.
Open field test and new object recognition task were performed before surgery and on postoperative days (POD) 1, 3, and 7.
Compared with control group, the level of cytokines in plasma and hippocampus revealed an obvious increase in surgery groups.
The effect of brachial plexus block on decreasing cytokines was observed.
The rats exposed to surgery without brachial plexus block showed behavior impairment.
Our results indicated that nerve blockage could downregulate proinflammatory cytokines in hippocampus after humeral fixation surgery, which may ameliorate the postoperative cognitive dysfunction in young rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
He, Yi& Li, Zhi& Zuo, Yun-Xia. 2015. Nerve Blockage Attenuates Postoperative Inflammation in Hippocampus of Young Rat Model with Surgical Trauma. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072364
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
He, Yi…[et al.]. Nerve Blockage Attenuates Postoperative Inflammation in Hippocampus of Young Rat Model with Surgical Trauma. Mediators of Inflammation No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1072364
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
He, Yi& Li, Zhi& Zuo, Yun-Xia. Nerve Blockage Attenuates Postoperative Inflammation in Hippocampus of Young Rat Model with Surgical Trauma. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072364
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072364
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)