Nerve Blockage Attenuates Postoperative Inflammation in Hippocampus of Young Rat Model with Surgical Trauma
Joint Authors
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
It is hypothesized that central nervous system inflammation induced by systematic inflammation due to surgical trauma plays a critical role in postoperative cognitive dysfunction.
The potential inhibitory effect of nerve blockage with local anesthetics on peripheral inflammatory response has been reported.
We hypothesize that nerve blockage may be effective in reducing postoperative inflammation and cognitive decline.
The rats at the age of 4 weeks were subjected to general anesthesia and humeral fracture fixation, in combination with brachial plexus block, saline versus ropivacaine, respectively.
The rats from control group underwent general anesthesia only.
The expression of proinflammatory cytokines in plasma and in hippocampus was measured.
Open field test and new object recognition task were performed before surgery and on postoperative days (POD) 1, 3, and 7.
Compared with control group, the level of cytokines in plasma and hippocampus revealed an obvious increase in surgery groups.
The effect of brachial plexus block on decreasing cytokines was observed.
The rats exposed to surgery without brachial plexus block showed behavior impairment.
Our results indicated that nerve blockage could downregulate proinflammatory cytokines in hippocampus after humeral fixation surgery, which may ameliorate the postoperative cognitive dysfunction in young rats.
American Psychological Association (APA)
He, Yi& Li, Zhi& Zuo, Yun-Xia. 2015. Nerve Blockage Attenuates Postoperative Inflammation in Hippocampus of Young Rat Model with Surgical Trauma. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072364
Modern Language Association (MLA)
He, Yi…[et al.]. Nerve Blockage Attenuates Postoperative Inflammation in Hippocampus of Young Rat Model with Surgical Trauma. Mediators of Inflammation No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1072364
American Medical Association (AMA)
He, Yi& Li, Zhi& Zuo, Yun-Xia. Nerve Blockage Attenuates Postoperative Inflammation in Hippocampus of Young Rat Model with Surgical Trauma. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072364
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072364