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Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma
المؤلفون المشاركون
Braumüller, Sonja
Ehrnthaller, C.
Gebhard, F.
Denk, Stephanie
Wiegner, Rebecca
Hönes, Felix M.
Messerer, David A. C.
Radermacher, Peter
Kalbitz, Miriam
McCook, Oscar
Weckbach, Sebastian
Weiss, Manfred
Huber-Lang, Markus S.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-18
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Severe tissue trauma-induced systemic inflammation is often accompanied by evident or occult blood-organ barrier dysfunctions, frequently leading to multiple organ dysfunction.
However, it is unknown whether specific barrier molecules are shed into the circulation early after trauma as potential indicators of an initial barrier dysfunction.
The release of the barrier molecule junctional adhesion molecule-1 (JAM-1) was investigated in plasma of C57BL/6 mice 2 h after experimental mono- and polytrauma as well as in polytrauma patients (ISS ≥ 18) during a 10-day period.
Correlation analyses were performed to indicate a linkage between JAM-1 plasma concentrations and organ failure.
JAM-1 was systemically detected after experimental trauma in mice with blunt chest trauma as a driving force.
Accordingly, JAM-1 was reduced in lung tissue after pulmonary contusion and JAM-1 plasma levels significantly correlated with increased protein levels in the bronchoalveolar lavage as a sign for alveolocapillary barrier dysfunction.
Furthermore, JAM-1 was markedly released into the plasma of polytrauma patients as early as 4 h after the trauma insult and significantly correlated with severity of disease and organ dysfunction (APACHE II and SOFA score).
The data support an early injury- and time-dependent appearance of the barrier molecule JAM-1 in the circulation indicative of a commencing trauma-induced barrier dysfunction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Denk, Stephanie& Wiegner, Rebecca& Hönes, Felix M.& Messerer, David A. C.& Radermacher, Peter& Weiss, Manfred…[et al.]. 2015. Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072370
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Denk, Stephanie…[et al.]. Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma. Mediators of Inflammation No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1072370
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Denk, Stephanie& Wiegner, Rebecca& Hönes, Felix M.& Messerer, David A. C.& Radermacher, Peter& Weiss, Manfred…[et al.]. Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072370
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072370
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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