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Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma
Joint Authors
Braumüller, Sonja
Ehrnthaller, C.
Gebhard, F.
Denk, Stephanie
Wiegner, Rebecca
Hönes, Felix M.
Messerer, David A. C.
Radermacher, Peter
Kalbitz, Miriam
McCook, Oscar
Weckbach, Sebastian
Weiss, Manfred
Huber-Lang, Markus S.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Severe tissue trauma-induced systemic inflammation is often accompanied by evident or occult blood-organ barrier dysfunctions, frequently leading to multiple organ dysfunction.
However, it is unknown whether specific barrier molecules are shed into the circulation early after trauma as potential indicators of an initial barrier dysfunction.
The release of the barrier molecule junctional adhesion molecule-1 (JAM-1) was investigated in plasma of C57BL/6 mice 2 h after experimental mono- and polytrauma as well as in polytrauma patients (ISS ≥ 18) during a 10-day period.
Correlation analyses were performed to indicate a linkage between JAM-1 plasma concentrations and organ failure.
JAM-1 was systemically detected after experimental trauma in mice with blunt chest trauma as a driving force.
Accordingly, JAM-1 was reduced in lung tissue after pulmonary contusion and JAM-1 plasma levels significantly correlated with increased protein levels in the bronchoalveolar lavage as a sign for alveolocapillary barrier dysfunction.
Furthermore, JAM-1 was markedly released into the plasma of polytrauma patients as early as 4 h after the trauma insult and significantly correlated with severity of disease and organ dysfunction (APACHE II and SOFA score).
The data support an early injury- and time-dependent appearance of the barrier molecule JAM-1 in the circulation indicative of a commencing trauma-induced barrier dysfunction.
American Psychological Association (APA)
Denk, Stephanie& Wiegner, Rebecca& Hönes, Felix M.& Messerer, David A. C.& Radermacher, Peter& Weiss, Manfred…[et al.]. 2015. Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072370
Modern Language Association (MLA)
Denk, Stephanie…[et al.]. Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma. Mediators of Inflammation No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1072370
American Medical Association (AMA)
Denk, Stephanie& Wiegner, Rebecca& Hönes, Felix M.& Messerer, David A. C.& Radermacher, Peter& Weiss, Manfred…[et al.]. Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072370
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072370