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Effect of Helicobacter pylori Eradication on TLR2 and TLR4 Expression in Patients with Gastric Lesions
المؤلفون المشاركون
Goloni-Bertollo, Eny Maria
Matos Biselli-Périco, Joice
Fucuta Pereira, Patrícia
Do Vale, Edla Polsinelli Bedin Mascarin
Acayaba, Ricardo
Leite, Kátia Ramos Moreira
Rossi, Ana Flávia Teixeira
Cadamuro, Aline Cristina Targa
Silva, Ana Elizabete
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
Helicobacter pylori (Hp) is recognized by TLR4 and TLR2 receptors, which trigger the activation of genes involved in the host immune response.
Thus, we evaluated the effect of eradication therapy on TLR2 and TLR4 mRNA and protein expression in H.
pylori-infected chronic gastritis patients (CG-Hp+) and 3 months after treatment.
Methods.
A total of 37 patients CG-Hp+ were evaluated.
The relative quantification (RQ) of mRNA was assessed by TaqMan assay and protein expression by immunohistochemistry.
Results.
Before treatment both TLR2 and TLR4 mRNA in CG-Hp+ patients were slightly increased (TLR2 = 1.32; TLR4 = 1.26) in relation to Hp-negative normal gastric mucosa (P≤0.05).
After successful eradication therapy no significant change was observed (TLR2 = 1.47; TLR4 = 1.53; P>0.05).
In addition, the cagA and vacA bacterial genotypes did not influence the gene expression levels, and we observed a positive correlation between the RQ values of TLR2 and TLR4, both before and after treatment.
Immunoexpression of the TLR2 and TLR4 proteins confirmed the gene expression results.
Conclusion.
In conclusion, the expression of both TLR2 and TLR4 is increased in CG-Hp+ patients regardless of cagA and vacA status and this expression pattern is not significantly changed after eradication of bacteria, at least for the short period of time evaluated.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cadamuro, Aline Cristina Targa& Rossi, Ana Flávia Teixeira& Matos Biselli-Périco, Joice& Fucuta Pereira, Patrícia& Do Vale, Edla Polsinelli Bedin Mascarin& Acayaba, Ricardo…[et al.]. 2015. Effect of Helicobacter pylori Eradication on TLR2 and TLR4 Expression in Patients with Gastric Lesions. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072376
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cadamuro, Aline Cristina Targa…[et al.]. Effect of Helicobacter pylori Eradication on TLR2 and TLR4 Expression in Patients with Gastric Lesions. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072376
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cadamuro, Aline Cristina Targa& Rossi, Ana Flávia Teixeira& Matos Biselli-Périco, Joice& Fucuta Pereira, Patrícia& Do Vale, Edla Polsinelli Bedin Mascarin& Acayaba, Ricardo…[et al.]. Effect of Helicobacter pylori Eradication on TLR2 and TLR4 Expression in Patients with Gastric Lesions. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072376
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072376
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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