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Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine
المؤلفون المشاركون
Menezes, Gustavo Batista
Vilela, Luciano Rezende
Gomides, Lindisley Ferreira
David, Bruna Araújo
Antunes, Maísa Mota
Diniz, Ariane Barros
Moreira, Fabrício de Araújo
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-27
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Cocaine is a commonly abused illicit drug that causes significant morbidity and mortality.
The most severe and common complications are seizures, ischemic strokes, myocardial infarction, and acute liver injury.
Here, we demonstrated that acute cocaine intoxication promoted seizure along with acute liver damage in mice, with intense inflammatory infiltrate.
Considering the protective role of the endocannabinoid system against cell toxicity, we hypothesized that treatment with an anandamide hydrolysis inhibitor, URB597, or with a phytocannabinoid, cannabidiol (CBD), protects against cocaine toxicity.
URB597 (1.0 mg/kg) abolished cocaine-induced seizure, yet it did not protect against acute liver injury.
Using confocal liver intravital microscopy, we observed that CBD (30 mg/kg) reduced acute liver inflammation and damage induced by cocaine and prevented associated seizure.
Additionally, we showed that previous liver damage induced by another hepatotoxic drug (acetaminophen) increased seizure and lethality induced by cocaine intoxication, linking hepatotoxicity to seizure dynamics.
These findings suggest that activation of cannabinoid system may have protective actions on both liver and brain induced by cocaine, minimizing inflammatory injury promoted by cocaine, supporting its further clinical application in the treatment of cocaine abuse.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vilela, Luciano Rezende& Gomides, Lindisley Ferreira& David, Bruna Araújo& Antunes, Maísa Mota& Diniz, Ariane Barros& Moreira, Fabrício de Araújo…[et al.]. 2015. Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072404
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vilela, Luciano Rezende…[et al.]. Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine. Mediators of Inflammation No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1072404
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vilela, Luciano Rezende& Gomides, Lindisley Ferreira& David, Bruna Araújo& Antunes, Maísa Mota& Diniz, Ariane Barros& Moreira, Fabrício de Araújo…[et al.]. Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072404
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072404
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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