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Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine
Joint Authors
Menezes, Gustavo Batista
Vilela, Luciano Rezende
Gomides, Lindisley Ferreira
David, Bruna Araújo
Antunes, Maísa Mota
Diniz, Ariane Barros
Moreira, Fabrício de Araújo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Cocaine is a commonly abused illicit drug that causes significant morbidity and mortality.
The most severe and common complications are seizures, ischemic strokes, myocardial infarction, and acute liver injury.
Here, we demonstrated that acute cocaine intoxication promoted seizure along with acute liver damage in mice, with intense inflammatory infiltrate.
Considering the protective role of the endocannabinoid system against cell toxicity, we hypothesized that treatment with an anandamide hydrolysis inhibitor, URB597, or with a phytocannabinoid, cannabidiol (CBD), protects against cocaine toxicity.
URB597 (1.0 mg/kg) abolished cocaine-induced seizure, yet it did not protect against acute liver injury.
Using confocal liver intravital microscopy, we observed that CBD (30 mg/kg) reduced acute liver inflammation and damage induced by cocaine and prevented associated seizure.
Additionally, we showed that previous liver damage induced by another hepatotoxic drug (acetaminophen) increased seizure and lethality induced by cocaine intoxication, linking hepatotoxicity to seizure dynamics.
These findings suggest that activation of cannabinoid system may have protective actions on both liver and brain induced by cocaine, minimizing inflammatory injury promoted by cocaine, supporting its further clinical application in the treatment of cocaine abuse.
American Psychological Association (APA)
Vilela, Luciano Rezende& Gomides, Lindisley Ferreira& David, Bruna Araújo& Antunes, Maísa Mota& Diniz, Ariane Barros& Moreira, Fabrício de Araújo…[et al.]. 2015. Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072404
Modern Language Association (MLA)
Vilela, Luciano Rezende…[et al.]. Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine. Mediators of Inflammation No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1072404
American Medical Association (AMA)
Vilela, Luciano Rezende& Gomides, Lindisley Ferreira& David, Bruna Araújo& Antunes, Maísa Mota& Diniz, Ariane Barros& Moreira, Fabrício de Araújo…[et al.]. Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1072404
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072404