Notch Signaling Pathway Was Involved in Regulating Programmed Cell Death 1 Expression during Sepsis-Induced Immunosuppression
المؤلفون المشاركون
Pan, Tingting
Liu, Zhaojun
Yin, Jianyong
Zhou, Tianyun
Liu, Jialin
Qu, Hongping
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-04-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Programmed cell death 1 (PD-1) plays an important pathologic role in sepsis-induced immunosuppression.
However, whether PD-1 overexpression occurs early during septic shock is unknown and its regulation mechanism is also unknown.
Our study investigated the expressions of PD-1/programmed death-ligand 1 (PD-L1) on immune cells in peripheral blood from the early-stage septic shock patients.
We found that both PD-1 and PD-L1 showed increased expressions on the CD4+ T cells and monocytes.
It indicated that PD-1 expression might be an early biomarker to assess illness severity and predict the prognosis of septic shock.
Then, we further investigated the mechanism underlying the regulation of PD-1 expression.
Our data showed that Notch signaling pathway was activated in both septic shock patients and lipopolysaccharide- (LPS-) tolerant THP1 cells and both interleukin-10 (IL-10) and PD-1 were increased in the THP1 cells.
Inhibition of Notch signaling by N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenyl glycinet-butyl ester (DAPT) induced significantly decreased expressions of PD-1 and IL-10 in the LPS-tolerant cell model.
Our work suggested that Notch signaling pathway was involved in the regulation of PD-1 expression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pan, Tingting& Liu, Zhaojun& Yin, Jianyong& Zhou, Tianyun& Liu, Jialin& Qu, Hongping. 2015. Notch Signaling Pathway Was Involved in Regulating Programmed Cell Death 1 Expression during Sepsis-Induced Immunosuppression. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072415
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pan, Tingting…[et al.]. Notch Signaling Pathway Was Involved in Regulating Programmed Cell Death 1 Expression during Sepsis-Induced Immunosuppression. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072415
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pan, Tingting& Liu, Zhaojun& Yin, Jianyong& Zhou, Tianyun& Liu, Jialin& Qu, Hongping. Notch Signaling Pathway Was Involved in Regulating Programmed Cell Death 1 Expression during Sepsis-Induced Immunosuppression. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072415
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072415
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر