Notch Signaling Pathway Was Involved in Regulating Programmed Cell Death 1 Expression during Sepsis-Induced Immunosuppression
Joint Authors
Pan, Tingting
Liu, Zhaojun
Yin, Jianyong
Zhou, Tianyun
Liu, Jialin
Qu, Hongping
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Programmed cell death 1 (PD-1) plays an important pathologic role in sepsis-induced immunosuppression.
However, whether PD-1 overexpression occurs early during septic shock is unknown and its regulation mechanism is also unknown.
Our study investigated the expressions of PD-1/programmed death-ligand 1 (PD-L1) on immune cells in peripheral blood from the early-stage septic shock patients.
We found that both PD-1 and PD-L1 showed increased expressions on the CD4+ T cells and monocytes.
It indicated that PD-1 expression might be an early biomarker to assess illness severity and predict the prognosis of septic shock.
Then, we further investigated the mechanism underlying the regulation of PD-1 expression.
Our data showed that Notch signaling pathway was activated in both septic shock patients and lipopolysaccharide- (LPS-) tolerant THP1 cells and both interleukin-10 (IL-10) and PD-1 were increased in the THP1 cells.
Inhibition of Notch signaling by N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenyl glycinet-butyl ester (DAPT) induced significantly decreased expressions of PD-1 and IL-10 in the LPS-tolerant cell model.
Our work suggested that Notch signaling pathway was involved in the regulation of PD-1 expression.
American Psychological Association (APA)
Pan, Tingting& Liu, Zhaojun& Yin, Jianyong& Zhou, Tianyun& Liu, Jialin& Qu, Hongping. 2015. Notch Signaling Pathway Was Involved in Regulating Programmed Cell Death 1 Expression during Sepsis-Induced Immunosuppression. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072415
Modern Language Association (MLA)
Pan, Tingting…[et al.]. Notch Signaling Pathway Was Involved in Regulating Programmed Cell Death 1 Expression during Sepsis-Induced Immunosuppression. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072415
American Medical Association (AMA)
Pan, Tingting& Liu, Zhaojun& Yin, Jianyong& Zhou, Tianyun& Liu, Jialin& Qu, Hongping. Notch Signaling Pathway Was Involved in Regulating Programmed Cell Death 1 Expression during Sepsis-Induced Immunosuppression. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072415
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072415