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Collagen Induced Arthritis in DBA1J Mice Associates with Oxylipin Changes in Plasma
المؤلفون المشاركون
Vreeken, Rob J.
Harms, Amy C.
Hankemeier, Thomas
Berger, Ruud
He, Min
van Wijk, Eduard
Wang, Mei
Strassburg, Katrin
Schoeman, Johannes C.
van Wietmarschen, Herman
van der Greef, Jan
Kobayashi, Masaki
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-29
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Oxylipins play important roles in various biological processes and are considered as mediators of inflammation for a wide range of diseases such as rheumatoid arthritis (RA).
The purpose of this research was to study differences in oxylipin levels between a widely used collagen induced arthritis (CIA) mice model and healthy control (Ctrl) mice.
DBA/1J male mice (age: 6-7 weeks) were selected and randomly divided into two groups, namely, a CIA and a Ctrl group.
The CIA mice were injected intraperitoneally (i.p.) with the joint cartilage component collagen type II (CII) and an adjuvant injection of lipopolysaccharide (LPS).
Oxylipin metabolites were extracted from plasma for each individual sample using solid phase extraction (SPE) and were detected with high performance liquid chromatography/tandem mass spectrometry (HPLC-ESI-MS/MS), using dynamic multiple reaction monitoring (dMRM).
Both univariate and multivariate statistical analyses were applied.
The results in univariate Student’s t-test revealed 10 significantly up- or downregulated oxylipins in CIA mice, which were supplemented by another 6 additional oxylipins, contributing to group clustering upon multivariate analysis.
The dysregulation of these oxylipins revealed the presence of ROS-generated oxylipins and an increase of inflammation in CIA mice.
The results also suggested that the collagen induced arthritis might associate with dysregulation of apoptosis, possibly inhibited by activated NF-κB because of insufficient PPAR-γ ligands.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
He, Min& van Wijk, Eduard& Berger, Ruud& Wang, Mei& Strassburg, Katrin& Schoeman, Johannes C.…[et al.]. 2015. Collagen Induced Arthritis in DBA1J Mice Associates with Oxylipin Changes in Plasma. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072416
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
He, Min…[et al.]. Collagen Induced Arthritis in DBA1J Mice Associates with Oxylipin Changes in Plasma. Mediators of Inflammation No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1072416
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
He, Min& van Wijk, Eduard& Berger, Ruud& Wang, Mei& Strassburg, Katrin& Schoeman, Johannes C.…[et al.]. Collagen Induced Arthritis in DBA1J Mice Associates with Oxylipin Changes in Plasma. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072416
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072416
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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