The X-Linked Inhibitor of Apoptosis Protein Inhibitor Embelin Suppresses Inflammation and Bone Erosion in Collagen Antibody Induced Arthritis Mice
المؤلفون المشاركون
Crotti, Tania N.
Dharmapatni, Anak A. S. S. K.
Haynes, David R.
Cantley, Melissa D.
Marino, Victor
Perilli, Egon
Smith, Malcolm D.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-04
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the effect of Embelin, an inhibitor of X-Linked Inhibitor of Apoptosis Protein (XIAP), on inflammation and bone erosion in a collagen antibody induced arthritis (CAIA) in mice.
Methods.
Four groups of mice ( n = 6 per group) were allocated: CAIA untreated mice, CAIA treated with Prednisolone (10 mg/kg/day), CAIA treated with low dose Embelin (30 mg/kg/day), and CAIA treated with high dose Embelin (50 mg/kg/day).
Joint inflammation was evaluated using clinical paw score and histological assessments.
Bone erosion was assessed using micro-CT, tartrate resistant acid phosphatase (TRAP) staining, and serum carboxy-terminal collagen crosslinks (CTX-1) ELISA.
Immunohistochemistry was used to detect XIAP protein.
TUNEL was performed to identify apoptotic cells.
Results.
Low dose, but not high dose Embelin, suppressed inflammation as reflected by lower paw scores ( P < 0.05 ) and lower histological scores for inflammation.
Low dose Embelin reduced serum CTX-1 ( P < 0.05 ) and demonstrated lower histological score and TRAP counting, and slightly higher bone volume as compared to CAIA untreated mice.
XIAP expression was not reduced but TUNEL positive cells were more abundant in Embelin treated CAIA mice.
Conclusion.
Low dose Embelin suppressed inflammation and serum CTX-1 in CAIA mice, indicating a potential use for Embelin to treat pathological bone loss.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dharmapatni, Anak A. S. S. K.& Cantley, Melissa D.& Marino, Victor& Perilli, Egon& Crotti, Tania N.& Smith, Malcolm D.…[et al.]. 2015. The X-Linked Inhibitor of Apoptosis Protein Inhibitor Embelin Suppresses Inflammation and Bone Erosion in Collagen Antibody Induced Arthritis Mice. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072424
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dharmapatni, Anak A. S. S. K.…[et al.]. The X-Linked Inhibitor of Apoptosis Protein Inhibitor Embelin Suppresses Inflammation and Bone Erosion in Collagen Antibody Induced Arthritis Mice. Mediators of Inflammation No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1072424
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dharmapatni, Anak A. S. S. K.& Cantley, Melissa D.& Marino, Victor& Perilli, Egon& Crotti, Tania N.& Smith, Malcolm D.…[et al.]. The X-Linked Inhibitor of Apoptosis Protein Inhibitor Embelin Suppresses Inflammation and Bone Erosion in Collagen Antibody Induced Arthritis Mice. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1072424
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072424
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر