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Metalloproteinases and Their Tissue Inhibitors in Comparison between Different Chronic Pneumopathies in the Horse
المؤلفون المشاركون
Bondzio, Angelika
Einspanier, Ralf
Barton, Ann Kristin
Shety, Tarek
Gehlen, Heidrun
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
In chronic respiratory disease, matrix metalloproteinases (MMPs) contribute to pathological tissue destruction when expressed in excess, while tissue inhibitors of metalloproteinases (TIMPs) counteract MMPs with overexpression leading to fibrosis formation.
They may be out of balance in equine pneumopathies and serve as biomarkers of pulmonary inflammation.
We hypothesized that MMPs and TIMPs correlate to clinical findings and bronchoalveolar lavage fluid cytology in different equine chronic pneumopathies.
Using a scoring system, 61 horses were classified controls as free of respiratory disease (n=15), recurrent airway obstruction (RAO, n=17), inflammatory airway disease (IAD, n=18), or chronic interstitial pneumopathy (CIP, n=11).
Zymography and equine MMP and TIMP assays were used to detect MMP-2, MMP-8, MMP-9 as well as TIMP-1, and TIMP-2 in BALF supernatant.
MMP-2, TIMP-1, and TIMP-2 concentrations were significantly increased in RAO and IAD compared to controls.
MMP-9 concentration and MMP-8 activity evaluated by fluorimetry were significantly increased in RAO, IAD, and CIP.
These results were confirmed by zymography for MMP-2 and MMP-9 activity in 52 horses.
In conclusion, MMPs and TIMPs correlate well with clinical and cytologic findings.
These findings support the usefulness of MMPs, TIMPs, and their ratios to evaluate the severity of respiratory disease and may help to identify subclinical cases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Barton, Ann Kristin& Shety, Tarek& Bondzio, Angelika& Einspanier, Ralf& Gehlen, Heidrun. 2015. Metalloproteinases and Their Tissue Inhibitors in Comparison between Different Chronic Pneumopathies in the Horse. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072429
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Barton, Ann Kristin…[et al.]. Metalloproteinases and Their Tissue Inhibitors in Comparison between Different Chronic Pneumopathies in the Horse. Mediators of Inflammation No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1072429
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Barton, Ann Kristin& Shety, Tarek& Bondzio, Angelika& Einspanier, Ralf& Gehlen, Heidrun. Metalloproteinases and Their Tissue Inhibitors in Comparison between Different Chronic Pneumopathies in the Horse. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1072429
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072429
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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