The Immediate Intramedullary Nailing Surgery Increased the Mitochondrial DNA Release That Aggravated Systemic Inflammatory Response and Lung Injury Induced by Elderly Hip Fracture
المؤلفون المشاركون
Gan, Li
Zhong, Jianfeng
Zhang, Ruhui
Sun, Tiansheng
Li, Qi
Chen, Xiaobin
Zhang, Jianzheng
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-27
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Conventional concept suggests that immediate surgery is the optimal choice for elderly hip fracture patients; however, few studies focus on the adverse effect of immediate surgery.
This study aims to examine the adverse effect of immediate surgery, as well as to explore the meaning of mtDNA release after trauma.
In the experiment, elderly rats, respectively, received hip fracture operations or hip fracture plus intramedullary nail surgery.
After fracture operations, the serum mtDNA levels as well as the related indicators of systemic inflammatory response and lung injury significantly increased in the rats.
After immediate surgery, the above variables were further increased.
The serum mtDNA levels were significantly related with the serum cytokine (TNF-α and IL-10) levels and pulmonary histological score.
In order to identify the meaning of mtDNA release following hip fracture, the elderly rats received injections with mtDNA.
After treatment, the related indicators of systemic inflammatory response and lung injury significantly increased in the rats.
These results demonstrated that the immediate surgery increased the mtDNA release that could aggravate systemic inflammatory response and lung injury induced by elderly hip fracture; serum mtDNA might serve as a potential biomarker of systemic inflammatory response and lung injury following elderly hip fracture.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gan, Li& Zhong, Jianfeng& Zhang, Ruhui& Sun, Tiansheng& Li, Qi& Chen, Xiaobin…[et al.]. 2015. The Immediate Intramedullary Nailing Surgery Increased the Mitochondrial DNA Release That Aggravated Systemic Inflammatory Response and Lung Injury Induced by Elderly Hip Fracture. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072435
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gan, Li…[et al.]. The Immediate Intramedullary Nailing Surgery Increased the Mitochondrial DNA Release That Aggravated Systemic Inflammatory Response and Lung Injury Induced by Elderly Hip Fracture. Mediators of Inflammation No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1072435
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gan, Li& Zhong, Jianfeng& Zhang, Ruhui& Sun, Tiansheng& Li, Qi& Chen, Xiaobin…[et al.]. The Immediate Intramedullary Nailing Surgery Increased the Mitochondrial DNA Release That Aggravated Systemic Inflammatory Response and Lung Injury Induced by Elderly Hip Fracture. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072435
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072435
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر