The Immediate Intramedullary Nailing Surgery Increased the Mitochondrial DNA Release That Aggravated Systemic Inflammatory Response and Lung Injury Induced by Elderly Hip Fracture
Joint Authors
Gan, Li
Zhong, Jianfeng
Zhang, Ruhui
Sun, Tiansheng
Li, Qi
Chen, Xiaobin
Zhang, Jianzheng
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Conventional concept suggests that immediate surgery is the optimal choice for elderly hip fracture patients; however, few studies focus on the adverse effect of immediate surgery.
This study aims to examine the adverse effect of immediate surgery, as well as to explore the meaning of mtDNA release after trauma.
In the experiment, elderly rats, respectively, received hip fracture operations or hip fracture plus intramedullary nail surgery.
After fracture operations, the serum mtDNA levels as well as the related indicators of systemic inflammatory response and lung injury significantly increased in the rats.
After immediate surgery, the above variables were further increased.
The serum mtDNA levels were significantly related with the serum cytokine (TNF-α and IL-10) levels and pulmonary histological score.
In order to identify the meaning of mtDNA release following hip fracture, the elderly rats received injections with mtDNA.
After treatment, the related indicators of systemic inflammatory response and lung injury significantly increased in the rats.
These results demonstrated that the immediate surgery increased the mtDNA release that could aggravate systemic inflammatory response and lung injury induced by elderly hip fracture; serum mtDNA might serve as a potential biomarker of systemic inflammatory response and lung injury following elderly hip fracture.
American Psychological Association (APA)
Gan, Li& Zhong, Jianfeng& Zhang, Ruhui& Sun, Tiansheng& Li, Qi& Chen, Xiaobin…[et al.]. 2015. The Immediate Intramedullary Nailing Surgery Increased the Mitochondrial DNA Release That Aggravated Systemic Inflammatory Response and Lung Injury Induced by Elderly Hip Fracture. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072435
Modern Language Association (MLA)
Gan, Li…[et al.]. The Immediate Intramedullary Nailing Surgery Increased the Mitochondrial DNA Release That Aggravated Systemic Inflammatory Response and Lung Injury Induced by Elderly Hip Fracture. Mediators of Inflammation No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1072435
American Medical Association (AMA)
Gan, Li& Zhong, Jianfeng& Zhang, Ruhui& Sun, Tiansheng& Li, Qi& Chen, Xiaobin…[et al.]. The Immediate Intramedullary Nailing Surgery Increased the Mitochondrial DNA Release That Aggravated Systemic Inflammatory Response and Lung Injury Induced by Elderly Hip Fracture. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1072435
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072435