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Carbon Monoxide Inhibits Tenascin-C Mediated Inflammation via IL-10 Expression in a Septic Mouse Model
المؤلفون المشاركون
Li, Chun-shi
Zhang, Qinggao
Ryter, Stefan W.
Chen, Yingqing
Joe, Yeonsoo
Uddin, Md. Jamal
Chung, Hun Taeg
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-07
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Tenascin-C (TN-C), an extracellular matrix (ECM) glycoprotein, is specifically induced upon tissue injury and infection and during septic conditions.
Carbon monoxide (CO) gas is known to exert various anti-inflammatory effects in various inflammatory diseases.
However, the mechanisms underlying the effect of CO on TN-C-mediated inflammation are unknown.
In the present study, we found that treatment with LPS significantly enhanced TN-C expression in macrophages.
CO gas, or treatment with the CO-donor compound, CORM-2, dramatically reduced LPS-induced expression of TN-C and proinflammatory cytokines while significantly increased the expression of IL-10.
Treatment with TN-C siRNA significantly suppressed the effects of LPS on proinflammatory cytokines production.
TN-C siRNA did not affect the CORM-2-dependent increase of IL-10 expression.
In cells transfected with IL-10 siRNA, CORM-2 had no effect on the LPS-induced expression of TN-C and its downstream cytokines.
These data suggest that IL-10 mediates the inhibitory effect of CO on TN-C and the downstream production of proinflammatory cytokines.
Additionally, administration of CORM-2 dramatically reduced LPS-induced TN-C and proinflammatory cytokines production while expression of IL-10 was significantly increased.
In conclusion, CO regulated IL-10 expression and thus inhibited TN-C-mediated inflammation in vitro and in vivo.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Uddin, Md. Jamal& Li, Chun-shi& Joe, Yeonsoo& Chen, Yingqing& Zhang, Qinggao& Ryter, Stefan W.…[et al.]. 2015. Carbon Monoxide Inhibits Tenascin-C Mediated Inflammation via IL-10 Expression in a Septic Mouse Model. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1072454
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Uddin, Md. Jamal…[et al.]. Carbon Monoxide Inhibits Tenascin-C Mediated Inflammation via IL-10 Expression in a Septic Mouse Model. Mediators of Inflammation No. 2015 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1072454
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Uddin, Md. Jamal& Li, Chun-shi& Joe, Yeonsoo& Chen, Yingqing& Zhang, Qinggao& Ryter, Stefan W.…[et al.]. Carbon Monoxide Inhibits Tenascin-C Mediated Inflammation via IL-10 Expression in a Septic Mouse Model. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-14.
https://search.emarefa.net/detail/BIM-1072454
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072454
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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