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Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases
المؤلفون المشاركون
Libert, Claude
Vandenbroucke, Roosmarijn E.
Balusu, S.
Brkic, Marjana
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-27، 27ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-11
دولة النشر
مصر
عدد الصفحات
27
التخصصات الرئيسية
الملخص EN
Neurodegeneration is a chronic progressive loss of neuronal cells leading to deterioration of central nervous system (CNS) functionality.
It has been shown that neuroinflammation precedes neurodegeneration in various neurodegenerative diseases.
Matrix metalloproteinases (MMPs), a protein family of zinc-containing endopeptidases, are essential in (neuro)inflammation and might be involved in neurodegeneration.
Although MMPs are indispensable for physiological development and functioning of the organism, they are often referred to as double-edged swords due to their ability to also inflict substantial damage in various pathological conditions.
MMP activity is strictly controlled, and its dysregulation leads to a variety of pathologies.
Investigation of their potential use as therapeutic targets requires a better understanding of their contributions to the development of neurodegenerative diseases.
Here, we review MMPs and their roles in neurodegenerative diseases: Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), and multiple sclerosis (MS).
We also discuss MMP inhibition as a possible therapeutic strategy to treat neurodegenerative diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Brkic, Marjana& Balusu, S.& Libert, Claude& Vandenbroucke, Roosmarijn E.. 2015. Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-27.
https://search.emarefa.net/detail/BIM-1072459
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Brkic, Marjana…[et al.]. Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases. Mediators of Inflammation No. 2015 (2015), pp.1-27.
https://search.emarefa.net/detail/BIM-1072459
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Brkic, Marjana& Balusu, S.& Libert, Claude& Vandenbroucke, Roosmarijn E.. Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-27.
https://search.emarefa.net/detail/BIM-1072459
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072459
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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