![](/images/graphics-bg.png)
Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases
Joint Authors
Libert, Claude
Vandenbroucke, Roosmarijn E.
Balusu, S.
Brkic, Marjana
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-27, 27 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-11
Country of Publication
Egypt
No. of Pages
27
Main Subjects
Abstract EN
Neurodegeneration is a chronic progressive loss of neuronal cells leading to deterioration of central nervous system (CNS) functionality.
It has been shown that neuroinflammation precedes neurodegeneration in various neurodegenerative diseases.
Matrix metalloproteinases (MMPs), a protein family of zinc-containing endopeptidases, are essential in (neuro)inflammation and might be involved in neurodegeneration.
Although MMPs are indispensable for physiological development and functioning of the organism, they are often referred to as double-edged swords due to their ability to also inflict substantial damage in various pathological conditions.
MMP activity is strictly controlled, and its dysregulation leads to a variety of pathologies.
Investigation of their potential use as therapeutic targets requires a better understanding of their contributions to the development of neurodegenerative diseases.
Here, we review MMPs and their roles in neurodegenerative diseases: Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), and multiple sclerosis (MS).
We also discuss MMP inhibition as a possible therapeutic strategy to treat neurodegenerative diseases.
American Psychological Association (APA)
Brkic, Marjana& Balusu, S.& Libert, Claude& Vandenbroucke, Roosmarijn E.. 2015. Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-27.
https://search.emarefa.net/detail/BIM-1072459
Modern Language Association (MLA)
Brkic, Marjana…[et al.]. Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases. Mediators of Inflammation No. 2015 (2015), pp.1-27.
https://search.emarefa.net/detail/BIM-1072459
American Medical Association (AMA)
Brkic, Marjana& Balusu, S.& Libert, Claude& Vandenbroucke, Roosmarijn E.. Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-27.
https://search.emarefa.net/detail/BIM-1072459
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072459