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Neutrophilic Bronchial Inflammation Correlates with Clinical and Functional Findings in Patients with Noncystic Fibrosis Bronchiectasis
المؤلفون المشاركون
Vagaggini, B.
Bacci, E.
Malagrinò, L.
Bilotta, Marta
Cianchetti, Silvana
Latorre, Manuela
Nieri, Dario
Roggi, Maria Adelaide
Paggiaro, Pierluigi
Dente, F. L.
Bartoli, M. L.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-27
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Neutrophilic bronchial inflammation is a main feature of bronchiectasis, but not much is known about its relationship with other disease features.
Aim.
To compare airway inflammatory markers with clinical and functional findings in subjects with stable noncystic fibrosis bronchiectasis (NCFB).
Methods.
152 NFCB patients (62.6 years; females: 57.2%) underwent clinical and functional cross-sectional evaluation, including microbiologic and inflammatory cell profile in sputum, and exhaled breath condensate malondialdehyde (EBC-MDA).
NFCB severity was assessed using BSI and FACED criteria.
Results.
Sputum neutrophil percentages inversely correlated with FEV1 (P<0.0001; rho = −0.428), weakly with Leicester Cough Questionnaire score (P=0.068; rho = −0.58), and directly with duration of the disease (P=0.004; rho = 0.3) and BSI severity score (P=0.005; rho = 0.37), but not with FACED.
Sputum neutrophilia was higher in colonized subjects, P.
aeruginosa colonized subjects showing greater sputum neutrophilia and lower FEV1.
Patients with ≥3 exacerbations in the last year showed a significantly greater EBC-MDA than the remaining patients.
Conclusions.
Sputum neutrophilic inflammation and biomarkers of oxidative stress in EBC can be considered good biomarkers of disease severity in NCFB patients, as confirmed by pulmonary function, disease duration, bacterial colonization, BSI score, and exacerbation rate.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dente, F. L.& Bilotta, Marta& Bartoli, M. L.& Bacci, E.& Cianchetti, Silvana& Latorre, Manuela…[et al.]. 2015. Neutrophilic Bronchial Inflammation Correlates with Clinical and Functional Findings in Patients with Noncystic Fibrosis Bronchiectasis. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1072483
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dente, F. L.…[et al.]. Neutrophilic Bronchial Inflammation Correlates with Clinical and Functional Findings in Patients with Noncystic Fibrosis Bronchiectasis. Mediators of Inflammation No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1072483
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dente, F. L.& Bilotta, Marta& Bartoli, M. L.& Bacci, E.& Cianchetti, Silvana& Latorre, Manuela…[et al.]. Neutrophilic Bronchial Inflammation Correlates with Clinical and Functional Findings in Patients with Noncystic Fibrosis Bronchiectasis. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1072483
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072483
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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