Neutrophilic Bronchial Inflammation Correlates with Clinical and Functional Findings in Patients with Noncystic Fibrosis Bronchiectasis
Joint Authors
Vagaggini, B.
Bacci, E.
Malagrinò, L.
Bilotta, Marta
Cianchetti, Silvana
Latorre, Manuela
Nieri, Dario
Roggi, Maria Adelaide
Paggiaro, Pierluigi
Dente, F. L.
Bartoli, M. L.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Neutrophilic bronchial inflammation is a main feature of bronchiectasis, but not much is known about its relationship with other disease features.
Aim.
To compare airway inflammatory markers with clinical and functional findings in subjects with stable noncystic fibrosis bronchiectasis (NCFB).
Methods.
152 NFCB patients (62.6 years; females: 57.2%) underwent clinical and functional cross-sectional evaluation, including microbiologic and inflammatory cell profile in sputum, and exhaled breath condensate malondialdehyde (EBC-MDA).
NFCB severity was assessed using BSI and FACED criteria.
Results.
Sputum neutrophil percentages inversely correlated with FEV1 (P<0.0001; rho = −0.428), weakly with Leicester Cough Questionnaire score (P=0.068; rho = −0.58), and directly with duration of the disease (P=0.004; rho = 0.3) and BSI severity score (P=0.005; rho = 0.37), but not with FACED.
Sputum neutrophilia was higher in colonized subjects, P.
aeruginosa colonized subjects showing greater sputum neutrophilia and lower FEV1.
Patients with ≥3 exacerbations in the last year showed a significantly greater EBC-MDA than the remaining patients.
Conclusions.
Sputum neutrophilic inflammation and biomarkers of oxidative stress in EBC can be considered good biomarkers of disease severity in NCFB patients, as confirmed by pulmonary function, disease duration, bacterial colonization, BSI score, and exacerbation rate.
American Psychological Association (APA)
Dente, F. L.& Bilotta, Marta& Bartoli, M. L.& Bacci, E.& Cianchetti, Silvana& Latorre, Manuela…[et al.]. 2015. Neutrophilic Bronchial Inflammation Correlates with Clinical and Functional Findings in Patients with Noncystic Fibrosis Bronchiectasis. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1072483
Modern Language Association (MLA)
Dente, F. L.…[et al.]. Neutrophilic Bronchial Inflammation Correlates with Clinical and Functional Findings in Patients with Noncystic Fibrosis Bronchiectasis. Mediators of Inflammation No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1072483
American Medical Association (AMA)
Dente, F. L.& Bilotta, Marta& Bartoli, M. L.& Bacci, E.& Cianchetti, Silvana& Latorre, Manuela…[et al.]. Neutrophilic Bronchial Inflammation Correlates with Clinical and Functional Findings in Patients with Noncystic Fibrosis Bronchiectasis. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1072483
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1072483