ROS-Mediated NLRP3 Inflammasome Activity Is Essential for Burn-Induced Acute Lung Injury
المؤلفون المشاركون
Li, Jun
Han, Shichao
Cai, Weixia
Yang, Xuekang
Jia, Yanhui
Zheng, Zhao
Wang, Hongtao
Li, Yan
Gao, Jianxin
Fan, Lei
Hu, Dahai
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-20
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
The NLRP3 inflammasome is necessary for initiating acute sterile inflammation.
However, its role in the pathogenesis of burn-induced acute lung injury (ALI) is unknown.
This study aimed to determine the role of the NLRP3 inflammasome and the signaling pathways involved in burn-induced ALI.
We observed that the rat lungs exhibited enhanced inflammasome activity after burn, as evidenced by increased levels of NLRP3 expression and Caspase-1 activity and augmented inflammatory cytokines.
Inhibition of NLRP3 inflammasome by BAY11-7082 attenuated burn-induced ALI, as demonstrated by the concomitant remission of histopathologic changes and the reduction of myeloperoxidase (MPO) activity, inflammatory cytokines in rat lung tissue, and protein concentrations in the bronchoalveolar lavage fluid (BALF).
In the in vitro experiments, we used AMs (alveolar macrophages) challenged with burn serum to mimic the postburn microenvironment and noted that the serum significantly upregulated NLRP3 inflammasome signaling and reactive oxygen species (ROS) production.
The use of ROS scavenger N-acetylcysteine (NAC) partially reversed NLRP3 inflammasome activity in cells exposed to burn serum.
These results indicate that the NLRP3 inflammasome plays an essential role in burn-induced ALI and that burn-induced NLRP3 inflammasome activity is a partly ROS-dependent process.
Targeting this axis may represent a promising therapeutic strategy for the treatment of burn-induced ALI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Han, Shichao& Cai, Weixia& Yang, Xuekang& Jia, Yanhui& Zheng, Zhao& Wang, Hongtao…[et al.]. 2015. ROS-Mediated NLRP3 Inflammasome Activity Is Essential for Burn-Induced Acute Lung Injury. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1072531
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Han, Shichao…[et al.]. ROS-Mediated NLRP3 Inflammasome Activity Is Essential for Burn-Induced Acute Lung Injury. Mediators of Inflammation No. 2015 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1072531
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Han, Shichao& Cai, Weixia& Yang, Xuekang& Jia, Yanhui& Zheng, Zhao& Wang, Hongtao…[et al.]. ROS-Mediated NLRP3 Inflammasome Activity Is Essential for Burn-Induced Acute Lung Injury. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-16.
https://search.emarefa.net/detail/BIM-1072531
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1072531
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر