Serum IL-6 and IL-23 Levels and Their Correlation with Angiogenic Cytokines and Disease Activity in Ankylosing Spondylitis, Psoriatic Arthritis, and SAPHO Syndrome

المؤلفون المشاركون

Przepiera-Będzak, Hanna
Fischer, Katarzyna
Brzosko, Marek

المصدر

Mediators of Inflammation

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-08-03

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الأمراض

الملخص EN

Objectives.

To assess serum interleukin-6 (IL-6) and interleukin-23 (IL-23) and their correlation with angiogenic cytokines and disease activity in ankylosing spondylitis (AS), psoriatic arthritis (PsA), and SAPHO syndrome.

Patients and Methods.

We studied 152 spondyloarthritis (SpA) patients: 69 PsA, 61 AS, 22 SAPHO, and 29 controls.

We recorded age, sex, disease duration, and treatment.

We assessed BASDAI, VAS, and PASI scores.

Serum IL-6, IL-23, VEGF, EGF, FGFb, and FGFa levels were determined using ELISA.

We estimated ESR and CRP.

Results.

Serum IL-6 and IL-23 levels were higher in SpA than in control ( P < 0.00001 and P = 0.0004 , resp.).

There was a positive correlation between serum IL-6 and CRP in AS ( P = 0.000001 ), PsA ( P = 0.000001 ), and SAPHO ( P = 0.0003 ) patients.

There was a positive correlation between serum IL-6 and ESR in AS ( P = 0.000001 ), PsA ( P = 0.002 ), and SAPHO ( P = 0.02 ) patients.

There was no correlation of serum IL-6 and IL-23 with VAS, BASDAI, and angiogenic cytokines in SpA.

Conclusions.

Serum IL-6 but not serum IL-23 correlated with ESR and CRP in SpA.

No correlation was found of serum IL-6 and IL-23 with VAS, BASDAI, and angiogenic cytokines.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Przepiera-Będzak, Hanna& Fischer, Katarzyna& Brzosko, Marek. 2015. Serum IL-6 and IL-23 Levels and Their Correlation with Angiogenic Cytokines and Disease Activity in Ankylosing Spondylitis, Psoriatic Arthritis, and SAPHO Syndrome. Mediators of Inflammation،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072553

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Przepiera-Będzak, Hanna…[et al.]. Serum IL-6 and IL-23 Levels and Their Correlation with Angiogenic Cytokines and Disease Activity in Ankylosing Spondylitis, Psoriatic Arthritis, and SAPHO Syndrome. Mediators of Inflammation No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1072553

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Przepiera-Będzak, Hanna& Fischer, Katarzyna& Brzosko, Marek. Serum IL-6 and IL-23 Levels and Their Correlation with Angiogenic Cytokines and Disease Activity in Ankylosing Spondylitis, Psoriatic Arthritis, and SAPHO Syndrome. Mediators of Inflammation. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1072553

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1072553