Serum IL-6 and IL-23 Levels and Their Correlation with Angiogenic Cytokines and Disease Activity in Ankylosing Spondylitis, Psoriatic Arthritis, and SAPHO Syndrome

Abstract EN

Objectives.

To assess serum interleukin-6 (IL-6) and interleukin-23 (IL-23) and their correlation with angiogenic cytokines and disease activity in ankylosing spondylitis (AS), psoriatic arthritis (PsA), and SAPHO syndrome.

Patients and Methods.

We studied 152 spondyloarthritis (SpA) patients: 69 PsA, 61 AS, 22 SAPHO, and 29 controls.

We recorded age, sex, disease duration, and treatment.

We assessed BASDAI, VAS, and PASI scores.

Serum IL-6, IL-23, VEGF, EGF, FGFb, and FGFa levels were determined using ELISA.

We estimated ESR and CRP.

Results.

Serum IL-6 and IL-23 levels were higher in SpA than in control ( P < 0.00001 and P = 0.0004 , resp.).

There was a positive correlation between serum IL-6 and CRP in AS ( P = 0.000001 ), PsA ( P = 0.000001 ), and SAPHO ( P = 0.0003 ) patients.

There was a positive correlation between serum IL-6 and ESR in AS ( P = 0.000001 ), PsA ( P = 0.002 ), and SAPHO ( P = 0.02 ) patients.

There was no correlation of serum IL-6 and IL-23 with VAS, BASDAI, and angiogenic cytokines in SpA.

Conclusions.

Serum IL-6 but not serum IL-23 correlated with ESR and CRP in SpA.

No correlation was found of serum IL-6 and IL-23 with VAS, BASDAI, and angiogenic cytokines.